Clinical relevance of PD-L1 and PD-L2 overexpression in patients with esophageal squamous cell carcinoma

Journal of Thoracic Disease
Chih-Cheng HsiehYann-Jang Chen

Abstract

Even with the advance of diagnosis and the treatment, the 5-year survival rate for esophageal cancer patients is still poor. The checkpoint protein inhibition provides another choice to improve the survival. The expression of the programmed death ligand-1 (PD-L1) was reported but the clinical relevance remained inconsistent in esophageal cancer. Besides, there were few references about the other ligand, programed death ligand-2 (PD-L2). In this study, we evaluated the expressions of PD-L1 and PD-L2 in patients with esophageal squamous cell carcinoma (ESCC) and assessed their clinical relevance. From 1996 to 2011, 150 patients undergone complete surgical resection for ESCC were enrolled. Clinical data were recorded. Expression of PD-L1 and PD-L2 on cytoplasm in paraffin embedded tumor samples were analyzed by immunohistochemistry staining and scored with a semi-quantitative method. Of the patients, 96 (64.0%) patients had PD-L1 overexpression and 63 (42.0%) had PD-L2 overexpression. There was a correlation between the expression of PD-L1 and PD-L2 (P<0.001). Patients without overexpression of PD-L1, pathological T1-2 and N0 status, pathological stage I-II and no post-operative adjuvant treatment had a better disease free surviva...Continue Reading

Citations

Mar 4, 2020·International Journal of Molecular Sciences·Caterina VivaldiLorenzo Fornaro
Dec 24, 2018·International Journal of Molecular Sciences·David VránaJanusz Jankowski
Feb 15, 2020·Scientific Reports·Isamu HoshinoHisahiro Matsubara
Aug 9, 2020·Cancer Management and Research·Peng HanFan Li
Feb 6, 2020·Molecular Carcinogenesis·Samantha M Y ChenJing H Wang
Jan 7, 2021·Cancer Science·Keita KatsuraharaEigo Otsuji
Feb 13, 2021·International Journal of Molecular Sciences·Siqi LiMasaki Ieda
Jun 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Honggang YingXueli Bai

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