Clinical relevance of polymorphonuclear (PMN-) elastase determination in semen and serum during infertility investigation

International Journal of Andrology
Waltraud Eggert-KruseThomas Strowitzki

Abstract

The polymorphonuclear (PMN) elastase is secreted by activated granulocytes and is widely used as a marker of male accessory gland infection. However, the clinical value of routine determination of seminal plasma (SP) PMN elastase in asymptomatic patients during infertility investigation has not clearly been established and not much is known about the significance of PMN-elastase levels in serum as a potential biochemical determinant associated with infection/inflammation of the male genital tract. This prospective study included a total of 221 asymptomatic males from unselected subfertile couples, to evaluate the relationship of (i) serum and (ii) same-day SP PMN elastase concentrations with established semen quality parameters, including sperm functional capacity, local antisperm antibodies (ASA), seminal leucocytes, and the outcome of semen cultures including typical sexually transmitted disease pathogens, and a potential association with patients' medical history and results of clinical andrological examination. Furthermore, couples were followed up for subsequent fertility (controlled for female infertility factors). The concentrations of PMN elastase in serum and in SP were not significantly related to semen quality [with ...Continue Reading

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Citations

Feb 6, 2010·International Journal of Andrology·K Tremellen, O Tunc
Jul 16, 2013·Journal of Reproductive Immunology·Sandro La VigneraAldo E Calogero
Jul 12, 2018·American Journal of Reproductive Immunology : AJRI·Giuseppe GrandeAlfredo Pontecorvi
Jul 12, 2020·Journal of Assisted Reproduction and Genetics·Fabiola ZambranoCarlos Hermosilla
Jun 26, 2021·The World Journal of Men's Health·Rakesh SharmaGiovanni M Colpi

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