Clinical relevance of quantified fundus autofluorescence in diabetic macular oedema

Eye
S YoshitakeN Yoshimura

Abstract

To quantify the signal intensity of fundus autofluorescence (FAF) and evaluate its association with visual function and optical coherence tomography (OCT) findings in diabetic macular oedema (DMO). We reviewed 103 eyes of 78 patients with DMO and 30 eyes of 22 patients without DMO. FAF images were acquired using Heidelberg Retina Angiograph 2, and the signal levels of FAF in the individual subfields of the Early Treatment Diabetic Retinopathy Study grid were measured. We evaluated the association between quantified FAF and the logMAR VA and OCT findings. One hundred and three eyes with DMO had lower FAF signal intensity levels in the parafoveal subfields compared with 30 eyes without DMO. The autofluorescence intensity in the parafoveal subfields was associated negatively with logMAR VA and the retinal thickness in the corresponding subfields. The autofluorescence levels in the parafoveal subfield, except the nasal subfield, were lower in eyes with autofluorescent cystoid spaces in the corresponding subfield than in those without autofluorescent cystoid spaces. The autofluorescence level in the central subfield was related to foveal cystoid spaces but not logMAR VA or retinal thickness in the corresponding area. Quantified FAF ...Continue Reading

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Citations

Jan 30, 2018·Asia-Pacific Journal of Ophthalmology·Dhariana Acón, Lihteh Wu
Feb 3, 2016·Journal of Diabetes Science and Technology·James Kang Hao GohTien Yin Wong
Sep 17, 2016·Expert Review of Medical Devices·Ana M Calvo-MarotoAlejandro Cerviño
Sep 15, 2020·Therapeutic Advances in Ophthalmology·Sergio E Hernández Da MotaRaul Vélez-Montoya
Dec 31, 2020·Journal of Clinical Medicine·Stela VujosevicStefano De Cillà

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