PMID: 8998408Dec 1, 1995Paper

Clinical relevance of response and improvement in psychopharmacology: European College of Neuropsychopharmacology

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology

Abstract

The use of responder categories may provide more clinically relevant information than mean differences on a severity scale but is not a definitive solution. Responder analysis is more useful in moderate illness than in mild or severe illness, depends on the timing of the analysis, and on the variance in the sample. Nevertheless, a statistically significant difference between drug and placebo treatment with respect to the percentage responders defined as a pre-established degree of reduction on a pivotal severity scale may provide the most objective information about clinical relevance yet available. Using distributions of categories of response may be less restrictive and provide a better description of results but more data are needed before conclusions can be reached. Effect size is an attractive, apparently simple method of establishing clinical relevance but criteria are lacking on cutoffs for accepting an effect size as relevant. There is a need for more information on patient samples, a better exploration of the conditions affecting response, and a better description of outcome than a single point. There are no accepted firm criteria for the clinical relevance of differences observed. There is insufficient precision in ou...Continue Reading

Citations

Oct 5, 2001·European Psychiatry : the Journal of the Association of European Psychiatrists·J G StorosumW van den Brink
Feb 3, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J G StorosumB J van Zwieten
May 20, 1999·Journal of Affective Disorders·P RosenzweigE Legangneux
Mar 16, 2001·Expert Opinion on Pharmacotherapy·S KasperE Hilger
Jul 10, 2009·The Cochrane Database of Systematic Reviews·Sarah F Tyson, Ruth M Kent

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