PMID: 9193456May 1, 1997Paper

Clinical relevance of transforming growth factor-beta 1 in the urine of patients with hepatocellular carcinoma

Medicine
J F TsaiJ H Tsai

Abstract

To assess the clinical relevance of transforming growth factor-beta 1 (TGF-beta 1) in the urine of patients with hepatocellular carcinoma (HCC), TGF-beta 1 was measured, by radioimmunoassay, in 140 patients with HCC, 50 cirrhotic patients, 30 patients with chronic active hepatitis, and 50 healthy controls. The results indicate that there were significantly increased urinary TGF-beta 1 levels in patients with HCC. Raised TGF-beta 1 levels were associated, in a dose-related fashion, with increased risk for development of HCC (odds ratio, 1.05, 95% confidence interval, 1.03-1.07). HCC patients with raised TGF-beta 1 levels had shorter survival than those with normal TGF-beta 1 levels (p = 0.038). TGF-beta 1 levels decreased after successful anticancer therapy (p < 0.0001). There was an inverse correlation between TGF-beta 1 and serum alpha-fetoprotein (AFP) (r = -0.199, p < 0.04). Receiver operating characteristics (ROC) curve analysis indicated that parallel determination of TGF-beta 1 and AFP significantly increased the sensitivity and diagnostic accuracy, with a high specificity. In conclusion, raised urinary TGF-beta 1 was associated with HCC development. It is a predictor of poor prognosis, and a tumor marker for diagnosis an...Continue Reading

References

Aug 1, 1977·Cancer·D S Chen, J L Sung
Oct 8, 1977·British Medical Journal
Mar 1, 1992·British Journal of Cancer·V M Macaulay
May 1, 1992·Cancer·S T PierceP DeSimone
Jul 1, 1992·Japanese Journal of Cancer Research : Gann·Y ShiraiY Matsuzawa
Jan 11, 1992·Journal of Cellular Biochemistry. Supplement·R J CoffeyW H Polk
Aug 1, 1992·Seminars in Liver Disease·C E Rogler, F V Chisari
Jul 1, 1992·Journal of Clinical Gastroenterology·T W Lissoos, B H Davis
Jun 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L Y ChuangJ F Tsai
May 1, 1991·Journal of Medical Virology·J E Jeng, J F Tsai
Jan 1, 1991·Progress in Growth Factor Research·N Fausto
Sep 15, 1990·International Journal of Cancer. Journal International Du Cancer·R AaslandJ R Lillehaug
Dec 1, 1990·Japanese Journal of Cancer Research : Gann·N ItoS Tarui
Feb 14, 1991·Biochemical and Biophysical Research Communications·K NakaoY Kusumoto
Apr 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E CarianiC Brechot
Feb 1, 1991·The Journal of Pathology·C M BartonN R Lemoine
Feb 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C N d'ArvilleR Williams
Dec 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T IsmailA J Strain
Jan 1, 1990·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M ItoE Tahara
Mar 1, 1990·Japanese Journal of Cancer Research : Gann·N ItoS Tarui
Jan 1, 1990·Annals of the New York Academy of Sciences·N FaustoL Braun
Aug 31, 1990·Biochemical and Biophysical Research Communications·K TakaishiS Tarui
Jan 1, 1990·Annual Review of Cell Biology·J Massagué

❮ Previous
Next ❯

Citations

Sep 17, 2010·Cancer Chemotherapy and Pharmacology·Emilia FransveaGianluigi Giannelli
Nov 10, 2000·International Journal of Radiation Oncology, Biology, Physics·J DicksonC M West
Aug 1, 2007·Biomarkers in Medicine·Nikki P Y LeeJohn M Luk
Mar 6, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Emilia FransveaGianluigi Giannelli
Aug 28, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Antonio MazzoccaGianluigi Giannelli
Dec 31, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Emilia FransveaGianluigi Giannelli
Dec 17, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Renumathy DhanasekaranLewis R Roberts
Feb 5, 2004·Social Science & Medicine·Yea-Ing Lotus ShyuHsiao-Chin Lee
Oct 30, 2016·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Hanan Hussein ShehataSafaa Saleh Mahmoud
Apr 22, 2005·Scandinavian Journal of Gastroenterology·J F TsaiC Y Dai
Apr 29, 2009·Rapid Communications in Mass Spectrometry : RCM·Long-Bin JengFuu-Jen Tsai
Feb 12, 2005·Carcinogenesis·Alexandra N M FischerWolfgang Mikulits
Apr 8, 2003·World Journal of Gastroenterology : WJG·Run-Zhou NiXian-Yong Meng
Mar 12, 2017·Journal of Experimental & Clinical Cancer Research : CR·Yali ZhouHongmei Yang
Jun 5, 2002·World Journal of Gastroenterology : WJG·Lun-Xiu Qin, Zhao-You Tang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.