Clinical Research Needs for the Management of Chronic Rhinosinusitis with Nasal Polyps in the New Era of Biologics: A National Institute of Allergy and Infectious Diseases Workshop.

The Journal of Allergy and Clinical Immunology. in Practice
Robert M NaclerioAlkis Togias

Abstract

The development of biologics targeting various aspects of type 2 inflammation for the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) will provide clinicians with powerful tools to help treat these patients. However, other therapies are also available, and positioning of biologics in a management algorithm will require comparative trials. In November 2019, the National Institute of Allergy and Infectious Diseases convened a workshop to consider potential future trial designs. Workshop participants represented a wide spectrum of clinical specialties, including otolaryngology, allergy, and pulmonary medicine, as well as expertise in CRSwNP pathophysiology and in trial methodology and statistics. The workshop discussed the current state of knowledge in CRSwNP and considered the advantages and disadvantages of various clinical trial or observational study designs and various clinical outcomes. The output from this workshop, which is presented in this report, will hopefully provide investigators with adequate information and ideas to design future studies and answer critical clinical questions. It will also help clinicians understand the current state of the management of CRSwNP and its gaps and be more able to interp...Continue Reading

Citations

Apr 21, 2020·International Journal of Laboratory Hematology·John L FraterHeesun J Rogers
Nov 24, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Claus BachertTanya M Laidlaw
Feb 18, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Jody TverskyAntoine Azar
Feb 7, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Anju T PetersSiddhesh Kamat
Mar 5, 2021·International Forum of Allergy & Rhinology·Alexander L SchneiderBruce K Tan
Feb 8, 2021·The Journal of Allergy and Clinical Immunology·Zachary M SolerTimothy L Smith
Jun 13, 2021·Otolaryngologic Clinics of North America·Lauren T Roland, Joshua M Levy
Jun 30, 2021·International Forum of Allergy & Rhinology·Jose L MattosZachary M Soler
Jul 13, 2021·International Forum of Allergy & Rhinology·Lauren T RolandJean Kim

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