Clinical response to pazopanib in a patient with endolymphatic sac tumor not associated with von Hippel-Lindau syndrome.

CNS Oncology
Thomas NelsonEric Vail

Abstract

Endolymphatic sac tumors (ELSTs) are rare, locally invasive, vascular tumors of the temporal bone. These lesions are associated with von Hippel-Lindau syndrome but may arise sporadically. Early surgical intervention is recommended to prevent permanent neurologic deficits; however, many ELSTs are unresectable or are subtotally resected due to neurovascular compromise. Chemotherapeutic salvage therapy in trials of neoplasms of associated syndromes has targeted angiogenesis with variable response. We present the case of a sporadic ELST, previously minimally responsive to bevacizumab, treated with pazopanib, a multi-kinase inhibitor and antiangiogenic, with good response. Cases such as our patient may demonstrate the utility of novel antiangiogenics in the treatment of these rare neoplasms, particularly when the tumor is unresectable or necessitates subtotal resection.

References

Nov 1, 1990·The Quarterly Journal of Medicine·E R MaherM A Ferguson-Smith
Mar 24, 2004·Journal of Neurosurgery·Daniel ChooEdward H Oldfield
Apr 14, 2004·Neurology·Marc C ChamberlainSusan Groshen
Jun 11, 2004·The New England Journal of Medicine·Russell R LonserEdward H Oldfield
Jul 9, 2004·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Stephen RodriguesJenny Turner
Jul 29, 2004·The Laryngoscope·Marlan R Hansen, William M Luxford
May 2, 2008·Skull Base : Official Journal of North American Skull Base Society ... [et Al.]·Rodney C DiazWayne T Shaia
Dec 31, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Teri N KreislHoward A Fine
Jun 19, 2009·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·E L BravoI Gill
Sep 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Henry S FriedmanTimothy Cloughesy
May 20, 2011·Nature·Peter Carmeliet, Rakesh K Jain
Nov 23, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E JonaschS F Matin
Feb 14, 2012·Auris, Nasus, Larynx·Sami Tanbouzi HusseiniMario Sanna
Dec 12, 2012·Journal of Internal Medicine·L Claesson-Welsh, M Welsh
Feb 13, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Diether LambrechtsStefan J Scherer
Apr 23, 2014·International Journal of Cancer. Journal International Du Cancer·Julien HadouxEric Baudin
Oct 30, 2018·Nucleic Acids Research·John G TateSimon A Forbes
May 6, 2019·International Journal of Surgery Case Reports·Afnan AlkhotaniYoussef Al-Said

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Citations

Jun 7, 2021·Neuropathology and Applied Neurobiology·Leonille SchweizerDavid Capper
Jun 15, 2021·Otolaryngologic Clinics of North America·Scott Raskin, Miriam Bornhorst

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Methods Mentioned

BETA
biopsy

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