PMID: 9536874Apr 16, 1998Paper

Clinical results of implantation of the Chirila keratoprosthesis in rabbits

The British Journal of Ophthalmology
C R HicksI J Constable

Abstract

An ideal keratoprosthesis (KPro) would closely resemble a donor corneal button in terms of its surgical handling, optics, and capacity to heal with host tissue in order to avoid many of the complications associated with the KPros which are currently in clinical use. This study was carried out to assess the long term clinical outcomes on implantation of the core and skirt poly(2-hydroxyethyl methacrylate) KPro in animals. 20 KPros were made and implanted as full thickness corneal replacements into rabbits and followed for up to 21 months to date. 80% of the prostheses have been retained, with a low incidence of complications such as cataract, glaucoma, and retroprosthetic membrane formation which are frequently associated with KPro surgery. KPros of this type may offer promise in the treatment of patients for whom penetrating keratoplasty with donor material carries a poor prognosis. Refinement of the KPro and further animal trials, including implantation into abnormal corneas, are however mandatory before human implantation could be planned.

References

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Citations

Feb 3, 2011·Journal of Materials Science. Materials in Medicine·Aihua MaNigel J Fullwood
May 3, 2002·Ophthalmology·Geoffrey J CrawfordIan J Constable
Feb 16, 2000·Progress in Retinal and Eye Research·C HicksI Constable
Jun 18, 2011·Eye·N JiráskováM Kalfertova
Jul 17, 2004·Cornea·Traian V ChirilaSarojini Vijayasekaran
Jul 15, 2005·Cornea·Celia R Hicks, Stephen Hamilton
Oct 18, 2005·Cornea·C R HicksD J Apple
Nov 30, 2006·Cornea·Celia R HicksMax Bulsara
Sep 12, 2000·Journal of Biomaterials Science. Polymer Edition·S VijayasekaranI J Constable
Oct 18, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Nada JiraskovaPavel Rozsival
Jun 6, 2000·The British Journal of Ophthalmology·S R SandemanA W Lloyd
Dec 2, 2005·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Traian V ChirilaJohn M Webb
Mar 24, 2018·Biofabrication·Eugen B PetcuPaul D Dalton
Jan 22, 2003·The Cochrane Database of Systematic Reviews·K McCormackUNKNOWN EU Hernia Trialists Collaboration
Feb 7, 2007·Expert Review of Medical Devices·Celia R HicksIan J Constable
Nov 26, 2010·Seminars in Ophthalmology·Li Zhang, Aaron Fay
May 11, 2021·Experimental Eye Research·Dominique GeoffrionMona Harissi-Dagher

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