Clinical results of proton beam therapy for twenty older patients with esophageal cancer

Radiology and Oncology
T OnoKenji Nemoto

Abstract

In an aging society, increasing number of older patients are diagnosed with esophageal cancer. The purpose of this study was to assess the clinical efficacy and safety of proton beam therapy for older patients with esophageal cancer. Older patients (age: ≥ 65 years) newly diagnosed with esophageal cancer between January 2009 and June 2013 were enrolled in this study. All patients underwent either proton beam therapy alone or proton beam therapy with initial X-ray irradiation. Toxicities were evaluated using the Common Terminology Criteria for Adverse Events version 4.0. Twenty patients were eligible for this study and all completed the treatment. The median age was 78 years (range: 65-89 years) and the median follow-up time was 26.5 months (range: 6-62 months). Seven patients had lymph node metastases and 10 had stage II/III cancer. The median dose of proton beam therapy was 72.6 Gy relative biological dose effectiveness (RBE) (range: 66-74.8 Gy [RBE]) for proton beam therapy alone and 33 Gy (RBE) (range: 30.8-39.6 Gy [RBE]; total dose range: 66.8-75.6 Gy [RBE]) for proton beam therapy with initial X-ray irradiation. The 2-year overall survival rate was 81.8% (95% confidence interval [CI]: 62.4%-100%), and the 2-year local cont...Continue Reading

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Citations

May 16, 2017·Expert Review of Anticancer Therapy·Mian Xi, Steven H Lin
Feb 6, 2018·Molecular and Clinical Oncology·Xiufang TianJiandong Zhang
Jul 13, 2020·Esophagus : Official Journal of the Japan Esophageal Society·Takashi Ono
Jul 25, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles B Simone
May 2, 2021·Clinical Oncology : a Journal of the Royal College of Radiologists·O NicholasS H Gwynne

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