Clinical results with subcutaneous implants containing 3-keto desogestrel

Contraception
S E OlssonE D Johansson

Abstract

Eight healthy women using one Silastic implant of 30 mm length filled with 3-keto desogestrel, the active metabolite of desogestrel, were studied for 36-664 days. The release rate of 3-keto desogestrel was quite constant and around 30 micrograms/day. No ovulations occurred. One woman was amenorrheic, while the others had different bleeding patterns, often with periods of spotting. No other side effects were recorded. The mean plasma levels of 3-keto desogestrel were 0.9 nmol/l after 1 month and 0.5 nmol/l after 12 months. 3-Keto desogestrel was less effective than testosterone, estradiol or levonorgestrel in displacing 3H-dihydrotestosterone from SHBG. It is concluded that contraception with 3-keto desogestrel delivered through an implant is a promising method for further investigation. With a single implant we found a duration of at least one year.

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Jan 16, 1995·The American Journal of Medicine·P D Darney
Mar 30, 1999·Contraception·H B Croxatto, L Mäkäräinen
Apr 2, 2003·Pharmacology, Biochemistry, and Behavior·Iveta BernatovaMariana Morris
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Feb 18, 2021·BMJ Sexual & Reproductive Health
Sep 7, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Edson Santos Ferreira-FilhoIsabel Cristina Esposito Sorpreso

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