Clinical Review: Familial Mediterranean Fever-An Overview of Pathogenesis, Symptoms, Ocular Manifestations, and Treatment

Ocular Immunology and Inflammation
Harry PetrushkinAli S Jawad

Abstract

Familial Mediterranean fever is an autoinflammatory multisystem disease, which most commonly affects patients from the Mediterranean basin. This review discusses the common polymorphisms in the MEFV gene as well as the role of pyrin in disease pathogenesis. Patients with familial Mediterranean fever typically develop peritonitis, pleuritis, arthritis, and fever. In addition, a number of authors have reported ophthalmic features. These case reports and series are further explored in this review. Colchicine has transformed the prognosis for patients with familial Mediterranean fever. The rationale for the use of colchicine, as well as the evidence for newer biologic agents is also covered.

References

Jan 1, 1978·Journal of Oral Pathology·D BenEzra, R Nussenblatt
Nov 1, 1978·[Kango gijutsu] : [Nursing technique]·S Sugiura
Jul 1, 1977·The British Journal of Ophthalmology·B Z BiednerC Geltman
May 1, 1985·Archives of Disease in Childhood·T HerlinB Hamborg-Petersen
Aug 15, 1985·American Journal of Ophthalmology·J ScharfS Zonis
Oct 31, 1974·The New England Journal of Medicine·C A DinarelloD W Alling
Dec 1, 1974·Annals of Internal Medicine·R C Goldstein, A D Schwabe
Dec 1, 1972·Archives of Ophthalmology·S A BaghdassarianA K Khachadurian
Jan 26, 1980·The Medical Journal of Australia·M D Smith, R C Angove
Jan 1, 1997·QJM : Monthly Journal of the Association of Physicians·H A Majeed, M Rawashdeh
Sep 1, 1997·Nature Genetics·UNKNOWN French FMF Consortium
Jan 24, 1998·QJM : Monthly Journal of the Association of Physicians·S KeesA Livneh
Mar 21, 1998·Lancet·E Ben-Chetrit, M Levy
Mar 24, 1998·Yonsei Medical Journal·C C ZouboulisC E Orfanos
Jan 21, 2000·Developments in Ophthalmology·D BenEzra
Jun 15, 2000·European Journal of Human Genetics : EJHG·N StoffmanM Shohat
Apr 26, 2001·Psychophysiology·M Martín-LoechesF J Rubia
Oct 20, 2001·Journal of Korean Medical Science·D BangK S Kwon
Jan 10, 2003·Nucleic Acids Research·Cyril Sarrauste de MenthièreIsabelle Touitou
Mar 27, 2003·Cornea·Igal LeibovitchAnat Loewenstein
Jul 1, 1959·A.M.A. Archives of Ophthalmology·I MICHAELSONM RACHMILEWITZ
Aug 10, 2004·Human Mutation·Isabelle TouitouCyril Sarrauste de Menthiere
Jan 12, 2005·Medicine·Mehmet TuncaUNKNOWN Turkish FMF Study Group
Jun 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jae Jin ChaeDaniel L Kastner
Jan 24, 2007·Seminars in Arthritis and Rheumatism·Yackov BerkunEldad Ben-Chetrit
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sudarshan SeshadriMark D Wewers
Apr 15, 2008·Human Mutation·Florian MilhavetIsabelle Touitou
May 10, 2008·European Journal of Ophthalmology·U E AltiparmakS Duman
Dec 20, 2008·Acta Ophthalmologica·Aylin KaralezliYonca Aydin Akova
Feb 6, 2009·Rheumatology·Fatos YalçinkayaAysin Bakkaloglu
Feb 26, 2009·Clinical Rheumatology·Salih KavukcuBurçak Tatli Güneş
Aug 18, 2009·Acta Ophthalmologica·Moshe Lazar, Levi Rothkoff
Oct 1, 2009·Arthritis and Rheumatism·Eldad Ben-Chetrit, Isabelle Touitou
Oct 23, 2010·Arthritis and Rheumatism·Helen J LachmannPhilip N Hawkins
Nov 16, 2010·Joint, Bone, Spine : Revue Du Rhumatisme·Isabelle Koné-PautIsabelle Touitou
Sep 29, 2011·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Sule Apras BilgenMeral Calguneri
Jan 17, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·M LidarP Langevitz

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Citations

Jul 30, 2016·Ocular Immunology and Inflammation·Emmett T CunninghamManfred Zierhut
Dec 18, 2018·Ocular Immunology and Inflammation·Sukru CekicSara Sebnem Kilic
Apr 17, 2016·QJM : Monthly Journal of the Association of Physicians·E MozdiakR Arasaradnam
Jan 4, 2017·Case Reports in Ophthalmological Medicine·Serdar OzatesMehmet Yasin Teke
Jan 16, 2021·Journal français d'ophtalmologie·S BelfaizaA Oubaaz
Dec 19, 2019·Ocular Immunology and Inflammation·ArifÜlkü Yener, AslıÇelebi Tayfur
Nov 24, 2020·Therapeutic Advances in Ophthalmology·Najiha RahmanAmeenat Lola Solebo

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