Clinical review: Healing in gastrointestinal anastomoses, part II

Microsurgery
C Kristian EnestvedtBlair A Jobe

Abstract

Complications arising from gastrointestinal anastomosis failures are a major source of morbidity and mortality. This review examines the effects of local blood flow on anastomotic healing, and discusses strategies for improving perfusion. Disruption of blood supply plays a significant role in the development of anastomotic leakage. Several methods have been suggested to improve perfusion. Omental pedicles have been employed as buttresses to promote angiogenesis, but efficacy in preventing anastomotic dehiscence has not been established. The administration of exogenous pharmacologic agents (such as vascular endothelial growth factor) is another potential strategy, although the oncological safety of this approach has been questioned. Two techniques which show promise in reducing anastomotic leakage rates include the vascular augmentation of grafts at risk for ischemia (supercharging) and ischemic conditioning (utilizing the delay phenomenon). Further studies of these strategies are needed to establish their efficacy and safety for routine use in gastrointestinal anastomoses.

References

Jun 1, 1995·American Journal of Surgery·J D Urschel
Dec 1, 1994·Annals of Plastic Surgery·R P Rand, M J Jurkiewicz
Feb 1, 1997·Experimental and Molecular Pathology·W F SeifertT Hendriks
Jan 9, 1999·Journal of Surgical Oncology·S AkiyamaH Takagi
Jun 4, 1999·BMJ : British Medical Journal·T D Henry
Nov 21, 2000·Journal of the American College of Surgeons·N H BoyleR C Mason
Jan 3, 2001·Seminars in Surgical Oncology·H C Chen, Y B Tang
Oct 17, 2001·Annals of Plastic Surgery·K I KawaiK Nakai
Mar 30, 2002·Annals of Surgical Oncology·Elisabeth A te VeldeInne H Borel Rinkes
Jul 27, 2002·Annals of Plastic Surgery·Ercan KaracaogluRichard J Zienowicz
Aug 13, 2002·Plastic and Reconstructive Surgery·Detlev ErdmannGregory S Georgiade
Sep 26, 2002·World Journal of Surgery·Tatsuya MiyazakiKatsuhiko Tsukada
Feb 13, 2003·The Journal of Thoracic and Cardiovascular Surgery·Reginald V N LordPeter V Danenberg
Jun 20, 2003·Annals of the New York Academy of Sciences·Yuval DorEli Keshet
Sep 16, 2003·Plastic and Reconstructive Surgery·Sakir UnalIsmail Cinel
May 29, 2004·Annals of Surgery·William C LineaweaverFeng Zhang
Jun 19, 2004·Langenbeck's Archives of Surgery·Wolfgang SchröderA H Hölscher
Jul 16, 2004·Plastic and Reconstructive Surgery·Minoru SakurabaSatoshi Ebihara
Jul 30, 2004·Journal of Surgical Oncology·Axel KleespiesChristiane J Bruns

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Citations

Apr 2, 2011·World Journal of Gastroenterology : WJG·Philipp Anton HolznerGoran Marjanovic
Feb 27, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·L A E PosmaT Hendriks
Feb 24, 2011·International Journal of Colorectal Disease·Marc H SchreinemacherNicole D Bouvy
Jul 1, 2014·The Journal of Surgical Research·Flávio D SabinoRuy G Marques
Nov 26, 2010·Current Opinion in Anaesthesiology·Ju-Mei Ng
Jun 19, 2015·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Yavuz PoyrazogluAhmet Korkmaz
Mar 4, 2014·The Journal of Surgical Research·Georgios GalanopoulosCharalambos Lazarides
Feb 10, 2012·The Journal of Surgical Research·Kerem KaramanMusa Akoglu
Mar 17, 2010·European Urology·Nathan LawrentschukManfred P Wirth
Aug 15, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Mahmoud A AmrMartin D Zielinski
Jun 14, 2014·Artificial Organs·Akira T KawaguchiHiroyasu Makuuchi
Oct 17, 2013·Journal of Tissue Engineering and Regenerative Medicine·Kenjiro HiraiYoshiharu Sakai
Sep 15, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M BludauW Schröder
Sep 3, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·N A HirstD G Jayne
Jul 12, 2011·American Journal of Surgery·Joe L KolkertRutger J Ploeg
Feb 15, 2011·Expert Opinion on Therapeutic Targets·Pamela J Hornby, Beverley A Moore
Oct 19, 2010·Gastroenterology Research and Practice·Heather A RedstoneDavid L Sigalet
Oct 27, 2017·Acta chirurgica Belgica·Laura Christina LandesInes Gockel
May 12, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·G ArmstrongD Jayne
Aug 14, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·C M LeeC E Kleyn
Nov 10, 2018·Obesity Surgery·Kurt E RobertsAndrew J Duffy

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