Clinical Review on the Utility of Fecal Microbiota Transplantation in Immunocompromised Patients

Current Gastroenterology Reports
Hamzah Abu-SbeihYinghong Wang

Abstract

Fecal microbiota transplantation (FMT) represents a promising management modality for Clostridium difficile infection (CDI). In immunocompromised patients, FMT is utilized for CDI as well as emerging non-CDI indications such as inflammatory bowel disease and graft versus host disease. PURPOSE OF REVIEW: This review aims to shed light on the safety and efficacy of FMT in immunocompromised patients, including patients suffering for human immunodeficiency virus infection, solid organ and hematopoietic stem cell transplant recipients, cancer patients, and patients on immunosuppressive therapies. RECENT FINDINGS: Though the body of evidence concerning the use of FMT in immunocompromised is growing, no clinical trials exist to date. Present literature weighs in favor of FMT in immunocompromised patients, with an acceptable adverse effect profile and minimal risk of infectious adverse events. Further large scale studies and randomized controlled trials to validate the utility of FMT in immunocompromised individuals will be a welcomed endeavor.

References

Feb 21, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Johannes AasJohan S Bakken
Nov 4, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Travis H SanchezUNKNOWN Adult/Adolescent Spectrum of HIV Disease Study Group
Mar 10, 2006·Diseases of the Colon and Rectum·Stuart McPhersonSimon J Panter
Mar 21, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Joseph F RodemannChristian D Stone
Sep 12, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Patricia MuñozEmilio Bouza
Jan 15, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Erik R DubberkeVictoria J Fraser
Feb 10, 2009·The Journal of Hospital Infection·D M AnthonyL Rafter
Jul 18, 2009·International Journal of Antimicrobial Agents·Stuart Johnson
Jan 12, 2010·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Marwan S AbougergiBernard G Jaar
Feb 4, 2011·The New England Journal of Medicine·Thomas J LouieUNKNOWN OPT-80-003 Clinical Study Group
May 5, 2011·Current Gastroenterology Reports·Daniel L Raines, Fred A Lopez
Dec 20, 2011·The Journal of Infection·Paul J ColliniDavid H Dockrell
Feb 1, 2012·The American Journal of Gastroenterology·Matthew J HamiltonAlexander Khoruts
Mar 14, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carolyn D AlonsoKieren A Marr
Oct 9, 2012·Current Opinion in Gastroenterology·Olga C Aroniadis, Lawrence J Brandt
Oct 9, 2012·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Mini KambojKent A Sepkowitz
Nov 6, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·K NeemannA Freifeld
Nov 20, 2012·The American Journal of Gastroenterology·Faming ZhangGuozhong Ji
May 2, 2013·Journal of Clinical Gastroenterology·Alexa R WeingardenAlexander Khoruts
May 10, 2013·Current HIV/AIDS Reports·Paul J ColliniDavid H Dockrell
May 22, 2013·Annals of Internal Medicine·Latesha Elopre, Martin Rodriguez
Jul 19, 2013·Current HIV/AIDS Reports·Serena Spudich
Jan 18, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R J Friedman-MoracoC S Kraft
Apr 20, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Philipp EhlermannHugo A Katus
Jun 5, 2014·Current Infectious Disease Reports·Carolyn D Alonso, Mini Kamboj
Jul 6, 2014·Journal of Immunology Research·Stefano BibbòGiovanni Cammarota
Feb 24, 2015·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Stefano Di BellaNicola Petrosillo
May 20, 2015·The American Journal of Gastroenterology·Kaija-Leena KolhoWillem M de Vos
Jul 5, 2015·Journal of Crohn's & Colitis·David BusquetsXavier Aldeguer

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Citations

May 3, 2021·European Journal of Haematology·Felix GoeserMarta Rebeca Cruz Aguilar
Jul 16, 2021·Scandinavian Journal of Gastroenterology·Simon Mark Dahl BaunwallChristian Lodberg Hvas
Nov 2, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bryan J SchneiderKathryn Bollin

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