Clinical review: The role of advanced glycation end products in progression and complications of diabetes

The Journal of Clinical Endocrinology and Metabolism
Su-Yen Goh, Mark E Cooper

Abstract

Diabetic complications appear to be multifactorial in origin, but in particular, the biochemical process of advanced glycation, which is accelerated in diabetes as a result of chronic hyperglycemia and increased oxidative stress, has been postulated to play a central role in these disorders. Advanced glycation involves the generation of a heterogenous group of chemical moieties known as advanced glycated end products (AGEs), this reaction occurring as a result of a nonenzymatic reaction with glucose interacting with proteins, lipids, and nucleic acids, and involves key intermediates such as methylglyoxal. In this review we report on how these AGEs may exert deleterious effects in diabetes, as well as address current strategies to interrupt the formation or action of AGEs. First, AGEs act directly to induce cross-linking of long-lived proteins such as collagen to promote vascular stiffness, and, thus, alter vascular structure and function. Second, AGEs can interact with certain receptors, such as the receptor for AGE, to induce intracellular signaling that leads to enhanced oxidative stress and elaboration of key proinflammatory and prosclerotic cytokines. Over the last decade, a large number of preclinical studies have been per...Continue Reading

Citations

Sep 13, 2011·Amino Acids·Ross Milne, Seymour Brownstein
Aug 2, 2011·Cardiovascular Drugs and Therapy·Ryo YoshimotoTatsuya Sawamura
Jul 26, 2008·Reviews in Endocrine & Metabolic Disorders·Sally A Madsen-Bouterse, Renu A Kowluru
Oct 12, 2012·In Vitro Cellular & Developmental Biology. Animal·Yi-Qun LuXing-Bo Cheng
May 19, 2011·Current Diabetes Reports·Hongliang ZongAlan W Stitt
Jul 2, 2010·Journal of Cardiovascular Translational Research·Shamjeet SinghPawan K Singal
Apr 1, 2009·Indian Journal of Clinical Biochemistry : IJCB·Kinnari Mistry, Kiran Kalia
Jul 7, 2011·Indian Journal of Clinical Biochemistry : IJCB·P P SinghPraveen Sharma
Jan 10, 2012·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Brittany LawEdie C Goldsmith
May 18, 2012·Journal of the American Chemical Society·Tina WangDavid A Spiegel
Jun 10, 2011·Journal of Agricultural and Food Chemistry·Chi-Hao WuGow-Chin Yen
May 26, 2011·Nature Reviews. Endocrinology·Helen Vlassara, Gary E Striker
May 5, 2010·Nature Reviews. Nephrology·John C RutledgeDennis W Wilson
Oct 10, 2008·The New England Journal of Medicine·John Chalmers, Mark E Cooper
Sep 12, 2008·The New England Journal of Medicine·Rury R HolmanH Andrew W Neil
May 14, 2009·Molecular & Cellular Proteomics : MCP·Jiaqian NiUNKNOWN Clinical Genomic and Proteomic AMD Study Group
Jun 6, 2009·Antioxidants & Redox Signaling·Anne Negre-SalvayreManuel Portero-Otín
Jun 17, 2011·Antioxidants & Redox Signaling·Martha LappasAlicia Jawerbaum
Apr 23, 2011·Diabetes Technology & Therapeutics·Dieuwke C BosHarold W de Valk
May 17, 2011·Diabetes Technology & Therapeutics·Aleksandra AraszkiewiczDorota Zozulinska-Ziolkiewicz
Nov 3, 2011·Diabetes Technology & Therapeutics·Marcella NebbiosoNicola Pescosolido
Nov 26, 2013·Genome Biology and Evolution·Raquel López-DíezBegoña Aguado
Aug 23, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maria F Lopes-VirellaUNKNOWN DCCT/EDIC Research Group
Jul 22, 2010·Menopause : the Journal of the North American Menopause Society·Evanthia Diamanti-KandarakisGeorge Creatsas
May 12, 2010·International Journal of Clinical Practice·S Del PratoUNKNOWN Global Partnership for Effective Diabetes Management
Oct 24, 2008·American Journal of Physiology. Cell Physiology·Qiong Huang, Nader Sheibani
Dec 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Li MengRama Natarajan
Oct 1, 2010·American Journal of Physiology. Renal Physiology·Hui Q PanMargot S Damaser
Oct 27, 2011·Experimental Diabetes Research·Chia-Chao WuYuh-Feng Lin
Jun 10, 2011·American Journal of Nephrology·Melinda T Coughlan, Josephine M Forbes
Jul 16, 2013·BMC Complementary and Alternative Medicine·Nattha JariyapamornkoonSirichai Adisakwattana
Dec 16, 2011·Arthritis Research & Therapy·Lodewijk de GrootMarcel D Posthumus
Apr 23, 2009·The Journal of Clinical Endocrinology and Metabolism·Ann V SchwartzUNKNOWN Health, Aging, and Body Composition Study

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.