Clinical risk factors associated with postoperative delirium and evaluation of delirium management and assessment team in lung and esophageal cancer patients

Journal of Pharmaceutical Health Care and Sciences
Kiminaka MurakawaToshiaki Sendo

Abstract

Delirium is an acute change in cognition and concentration that complicates the postoperative course. Patients who suffer delirium after surgery have an increased risk of persistent cognitive impairment, functional decline, and death. Postoperative delirium is also associated with an increased length of hospital stay and higher costs. With the goal of preventing delirium in postoperative patients, we organized a medical team from the Delirium Management and Assessment Center (D-mac) at Okayama University Hospital in January 2012. The team members consisted of physicians, pharmacists, nurses, and clinical psychologists. We retrospectively reviewed the medical records of patients with delirium to examine risk factors related to the patients' background. Fifty-nine postoperative patients with lung or esophageal cancer were investigated; 25% exhibited delirium during hospitalization. Multiple logistic regression analysis showed significant associations between the presence of delirium and a past history of delirium (odds ratio, 4.22; 95% CI, 1.10-16.2; p = 0.09) and use of benzodiazepine receptor agonists (odds ratio, 3.97; 95% CI, 1.09-14.5; p = 0.03). Intervention by the D-mac significantly reduced the rate of delirium episodes i...Continue Reading

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Citations

Sep 15, 2016·Interactive Cardiovascular and Thoracic Surgery·Ryo MiyataMinoru Aoki
May 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Samina Kausar, Andre O Falcao
Jan 1, 2019·Chemical Biology & Drug Design·Ranita PalPratim Kumar Chattaraj
Feb 6, 2017·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yuka NakamuraToshiaki Sendo
Apr 4, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yoshito TomimaruKeizo Dono
May 19, 2021·European Journal of Pharmacology·Daiki MatsumotoToshiaki Sendo

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