Clinical risk factors for anastomotic leakage after laparoscopic anterior resection for rectal cancer: a systematic review and meta-analysis

Surgical Endoscopy
Hui QuDong-song Bi

Abstract

Anastomotic leakage (AL) is a serious complication in laparoscopic rectal cancer surgery, and risk factors for AL are not well defined. Herein, we conducted a systematic review to quantify the clinicopathologic factors predictive for AL in patients who underwent laparoscopic anterior resection (LAR) for rectal cancer. A systematic search of electronic databases (PubMed, Embase, Cochrane CENTRAL, Scopus Database, and Wanfang Database) for studies published until August 2014 was performed. Cohort, case-control studies, and randomized controlled trials that examined clinical risk factors for AL were included. Fourteen studies (seven prospective and seven retrospective studies) involving 4580 patients met final inclusion criteria. From the pooled analyses, five demographic factors were found to be significantly associated with the development of AL, including male gender (OR 2.04, 95% CI 1.50-2.77), BMI ≥25 kg/m(2) (OR 1.46, 95% CI 1.00-2.14), ASA score >2 (OR 1.74, 95% CI 1.04-2.93, P = 0.04), tumor size >5 cm (OR 1.63, 95% CI 1.01-2.64, P = 0.05), and preoperative chemotherapy (OR 1.67, 95% CI 1.10-2.55, P = 0.02). Four operative factors were significantly associated with increased risk of AL, including longer operative time (95%...Continue Reading

References

Dec 8, 2004·The British Journal of Surgery·K C M J PeetersUNKNOWN Dutch Colorectal Cancer Group
Dec 21, 2004·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M T EriksenUNKNOWN Norwegian Rectal Cancer Group
Mar 25, 2005·Diseases of the Colon and Rectum·Graham BranaganUNKNOWN Wessex Colorectal Cancer Audit Working Group
Jun 16, 2005·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Claude PolliandGerard Champault
Sep 5, 2007·International Journal of Colorectal Disease·B LefebureF Michot
Jan 26, 2008·Diseases of the Colon and Rectum·Michael A StröhleinMarkus M Heiss
Mar 11, 2009·Diseases of the Colon and Rectum·Yong-Geul JohDong-Keun Lee
Jun 2, 2009·American Journal of Surgery·Jung Wook HuhYoung Jin Kim
Jul 3, 2009·Diseases of the Colon and Rectum·Jeffrey W MilsomToyooki Sonoda
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Nov 17, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·F JörgrenG Lindmark
Apr 17, 2010·Annals of Surgery·Bogdan C PaunW Donald Buie
Dec 15, 2010·Journal of the Korean Society of Coloproctology·Dong Hyun ChoiHyung Kyu Yang
Jun 9, 2012·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Seiichiro YamamotoSeiichiro Yamamoto
Sep 19, 2012·JAMA Surgery·Celeste Y KangMichael J Stamos
Jan 5, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jeonghyun KangKang Young Lee

❮ Previous
Next ❯

Citations

Sep 18, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Sami A ChadiSteven D Wexner
Oct 14, 2016·BMC Anesthesiology·C D DaleT Quasim
Oct 30, 2016·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Alessandra MaranoFelice Borghi
Feb 21, 2018·European Journal of Clinical Nutrition·Soo Young LeeHyeong Rok Kim
Jun 20, 2018·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Simone GuadagniLuca Morelli
Jan 25, 2018·Chinese Medical Journal·Zi-Kuo WangShuai Zhang
Jan 30, 2020·Khirurgiia·P S Pryn, V V Polovinkin
Apr 15, 2020·Scandinavian Journal of Gastroenterology·Zeyang ChenPengyuan Wang
Apr 27, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Sanjeev DayalTom Cecil
Nov 22, 2017·Gastroenterology Research and Practice·Sameh Hany Emile, Tito M Abd El-Hamed
Nov 30, 2019·Journal of Surgical Oncology·Gustavo A LaporteWilliam A Casteleins
Feb 13, 2020·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·Gyoung Tae NohKwang Ho Kim
Apr 23, 2020·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Ivan DimovAnna Nayouf
Nov 10, 2017·International Journal of Colorectal Disease·Ulrich WirthHans Martin Schardey
Mar 14, 2018·International Journal of Colorectal Disease·Ri Na YooHyungJin Kim
Aug 17, 2020·World Journal of Surgical Oncology·Marius KryzauskasTomas Poskus
Jul 31, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Z ShenY Ye

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.