Clinical risk factors for cytomegalovirus retinitis in patients with AIDS

Ophthalmology
William G HodgeAashish Goela

Abstract

To determine the clinical risk factors for cytomegalovirus (CMV) retinitis in patients with AIDS. A case-control study. The study included 120 patients in whom CMV retinitis had been diagnosed from 1990 through 1999 (cases) and 159 patients without CMV retinitis from the same period (controls). All individuals had AIDS and CD4 counts less than 50 cells/microl at the time of diagnosis of retinitis in the cases or on the corresponding date for the controls. Clinical risk factors were determined by history or physical examination. Confounders controlled for included CD4 count, hospital center, and a series of variables to control for confounding by drug treatment. Statistical analysis was performed by multivariate logistic regression. A systematic model-building strategy was developed from assumption testing to model building to model checking. MAIN VARIABLES MEASURED: Presence of visual symptoms, retinal microinfarctions (cotton-wool spots), history of opportunistic infections, and risk factors for human immunodeficiency virus acquisition were determined and compared in both groups. The following clinical risk factors were significant predictors of CMV retinitis: flashing lights or floaters (odds ratio [OR], 11.42; 95% confidence...Continue Reading

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Citations

Jun 7, 2012·Medical Microbiology and Immunology·Jens-Uwe VogelJindrich Cinatl
May 24, 2013·Japanese Journal of Ophthalmology·Yuko IwasakiKimio Murakami
Jun 14, 2006·International Ophthalmology Clinics·Torsten W Wiegand, Lucy H Y Young
Apr 15, 2014·Ocular Immunology and Inflammation·Jinesh M ShahStephen C Teoh
Dec 25, 2007·American Journal of Ophthalmology·Gary N HollandUNKNOWN UCLA CMV Retinitis Study Group
Dec 25, 2007·American Journal of Ophthalmology·Gary N HollandUNKNOWN Southern California HIV/Eye Consortium
Mar 8, 2006·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·William G HodgeMichel A Dionne
Jun 15, 2016·The British Journal of Ophthalmology·Prattana LeenasirimakulJeremy D Keenan

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