Clinical risk scoring system for predicting extended-spectrum β-lactamase-producing Escherichia coli infection in hospitalized patients

The Journal of Hospital Infection
K KengklaS Saokaew

Abstract

Extended spectrum β-lactamase-producing Escherichia coli (ESBL-EC) has important implications for infection control and empiric antibiotic prescribing. This study aims to develop a risk scoring system for predicting ESBL-EC infection based on local epidemiology. The study retrospectively collected eligible patients with a positive culture for E. coli during 2011 to 2014. The risk scoring system was developed using variables independently associated with ESBL-EC infection through logistic regression-based prediction. Area under the receiver-operator characteristic curve (AuROC) was determined to confirm the prediction power of the model. Predictors for ESBL-EC infection were male gender [odds ratio (OR): 1.53], age ≥55 years (OR: 1.50), healthcare-associated infection (OR: 3.21), hospital-acquired infection (OR: 2.28), sepsis (OR: 1.79), prolonged hospitalization (OR: 1.88), history of ESBL infection within one year (OR: 7.88), prior use of broad-spectrum cephalosporins within three months (OR: 12.92), and prior use of other antibiotics within three months (OR: 2.14). Points scored ranged from 0 to 47, and were divided into three groups based on diagnostic performance parameters: low risk (score: 0-8; 44.57%), moderate risk (sco...Continue Reading

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Citations

Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Zaira Raquel Palacios-BaenaUNKNOWN Spanish Network for Research in Infectious Diseases (REIPI)/European Study Group of Bloodstream Infectio
Nov 22, 2017·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Charlesnika T EvansKatie J Suda
Sep 6, 2017·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Wen-Pin TsengShey-Ying Chen
Oct 27, 2016·Current Opinion in Infectious Diseases·Matteo BassettiDavide Pecori
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Sep 16, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marion ElligsenNick Daneman
Mar 17, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Rebecca WangJudith A Anesi

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