Mar 27, 2020

Clinical Role of Serum Interleukin-17A in the Prediction of Refractory Mycoplasma pneumoniae Pneumonia in Children

Infection and Drug Resistance
Jiuling ZhaoXin Wang

Abstract

Mycoplasma pneumoniae pneumonia (MPP) is a common community-acquired pneumonia (CAP) in children, which may become refractory MPP (RMPP) to treatment. The purpose of this study was to evaluate the clinical utility of measuring serum interleukin (IL)-17A to predict RMPP. A retrospective clinical study at a single pediatric center included a review of the medical records of all children hospitalized for CAP between November 2015 and October 2019. The diagnosis of MPP was based on clinical presentation, chest radiography, and measurement of serum anti-Mycoplasma immunoglobulin IgM antibody titer using the microparticle agglutination method or sputum samples for Mycoplasma pneumoniae by PCR. Serum levels of IL-18 and IL-17A were determined by ELISA. Of the 625 children diagnosed with CAP, there were 154 children with MPP and without underlying diseases who were divided into a non-refractory MPP (NRMPP) group (n = 109) and a RMPP group (n = 45). The RMPP group had a higher incidence of tachypnea, cyanosis, hypoxia, segmental or lobar pneumonia, pleural effusion, and a longer period of hospitalization compared with NRMPP group (all P-values < 0.05). A serum IL-17A level above 10.8 pg/mL was a predictor for RMPP: area under the curve ...Continue Reading

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Mentioned in this Paper

Lactate Dehydrogenase
Anatomical Segmentation
Observation Method - Agglutination
Hypoxia
Tachypnea
Community Acquired Pneumonia
Diagnosis
Sputum Specimen
Study
Cytomegalovirus IgM Antibody

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