Clinical Safety and Efficacy of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation in Sensorineural Hearing Loss Patients

Journal of Audiology & Otology
Ho Seok LeeKyoung Ho Park

Abstract

Stem cell transplantation represents a promising therapy for several degenerating and necrotic diseases. In several animal studies, we could find hearing restoration after inoculation of the mesenchymal stem cells' as well as mesenchymal stem cells' differentiation of hair cells and spiral ganglion. But until now, no clinical study has been reported directly for the human being. In this pilot studies, we applied mesenchymal stem cells to human beings trans-venously. Although we verified the safety of the autologous bone marrow stem cell transplantation in sensorineural hearing loss patients but we could not achieve significant improvement in hearing.

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Citations

Oct 21, 2018·Cellular and Molecular Life Sciences : CMLS·Amandine CzajkowskiBrigitte Malgrange
Apr 24, 2020·Molecular Biology Reports·Kevin ChorathAlvaro Moreira
May 1, 2020·BMJ : British Medical Journal·Michael J McPhailDavid G Lott
Aug 17, 2020·International Journal of Molecular Sciences·Sho KanzakiKaoru Ogawa
May 26, 2021·Journal of the American Academy of Audiology·Jenna E BergmanAdrien A Eshraghi
Jul 3, 2021·Journal of Clinical Medicine·Reza KaboodkhaniFeridoun Karimi-Busheri
Aug 31, 2021·Frontiers in Cell and Developmental Biology·Yuan ZhangRenjie Chai
Sep 10, 2021·Cell Transplantation·Tetsuji Sekiya, Matthew C Holley

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