Clinical setting influences off-label and unlicensed prescribing in a paediatric teaching hospital

PloS One
Petra CzarniakBruce Sunderland

Abstract

To estimate the prevalence of off-label and unlicensed prescribing during 2008 at a major paediatric teaching hospital in Western Australia. A 12-month retrospective study was conducted at Princess Margaret Hospital using medication chart records randomly selected from 145,550 patient encounters from the Emergency Department, Inpatient Wards and Outpatient Clinics. Patient and prescribing data were collected. Drugs were classified as off-label or unlicensed based on Australian registration data. A hierarchical system of age, indication, route of administration and dosage was used. Drugs were classified according to the Anatomical Therapeutic Chemical Code. A total of 1,037 paediatric patients were selected where 2,654 prescriptions for 330 different drugs were prescribed to 699 patients (67.4%). Most off-label drugs (n = 295; 43.3%) were from the nervous system; a majority of unlicensed drugs were systemic hormonal preparations excluding sex hormones (n = 22, 32.4%). Inpatients were prescribed more off-label drugs than outpatients or Emergency Department patients (p < 0.0001). Most off-label prescribing occurred in infants and children (31.7% and 35.9% respectively) and the highest percentage of unlicensed prescribing (7.2%) oc...Continue Reading

References

Mar 1, 1997·The American Journal of Emergency Medicine·J P McKinzieK D Wrenn
Mar 6, 1998·BMJ : British Medical Journal·S TurnerI Choonara
May 18, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·S ConroyI Choonara
Mar 4, 2000·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·S AvenelC Danan
Jul 10, 2001·Paediatric Anaesthesia·S Conroy, V Peden
Apr 9, 2002·American Journal of Perinatology·Joseph BarrMatitiahu Berkovitch
Jul 24, 2002·European Journal of Clinical Pharmacology·G W 't JongJ N van den Anker
Nov 5, 2002·Pediatrics·Colm P F O'DonnellColin J Morley
Dec 19, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S ConroyS Gudka
May 6, 2004·International Journal of Clinical Pharmacology and Therapeutics·R Kitzes-CohenM Levy
Oct 9, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Antje NeubertBurkhard Hinz
Sep 10, 2005·European Journal of Clinical Pharmacology·M BajceticR Gorodischer
Feb 24, 2007·Journal of Paediatrics and Child Health·Yashwant Sinha, Noel E Cranswick
Jan 26, 2008·Pharmacy World & Science : PWS·Linda HsienStephanie Läer
Aug 8, 2008·European Journal of Clinical Pharmacology·Djanilson Barbosa SantosHelena Lutescia Luna Coelho
Jul 30, 2009·European Journal of Pediatrics·Fiona HealyRaezelle Zinman
Aug 5, 2009·Journal of Clinical Pharmacy and Therapeutics·L Lindell-OsuagwuH Kokki
Feb 7, 2012·European Journal of Clinical Pharmacology·Goran PalčevskiVera Vlahović-Palčevski
Apr 13, 2012·Swiss Medical Weekly·Ermindo R Di PaoloAndre Pannatier
Oct 12, 2012·International Journal of Clinical Pharmacy·Marina RibeiroAna Filipa Macedo
Dec 5, 2012·European Journal of Pediatrics·Davide ZanonGianni Messi
Jan 3, 2013·Journal of Paediatrics and Child Health·Christopher D J BallardSean A Beggs
Sep 12, 2013·International Journal of Clinical Pharmacy·Jian Lynn LeeNoraida Mohamed Shah

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Citations

Jan 20, 2017·European Journal of Clinical Pharmacology·Niina LaineHarri Saxen
Jun 10, 2017·International Journal of Clinical Pharmacy·Muhammad AamirSyed Muhammad Asim
May 18, 2017·European Journal of Endocrinology·Uta NeumannOliver Blankenstein
Jun 26, 2017·Thérapie·Christelle BerthodAudrey Lajoinie
Feb 8, 2018·British Journal of Clinical Pharmacology·Kate M ChittyNicholas A Buckley
Sep 16, 2018·World Journal of Pediatrics : WJP·Shamala BalanVivienne S L Mak
Jul 7, 2018·European Journal of Pediatrics·Elisabeth RauchChristoph Male
Aug 15, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Anwar A AlghamdiDarren M Ashcroft
Sep 8, 2018·Journal of Korean Medical Science·Ji-Hyun LeeHee-Soo Kim
Nov 30, 2019·British Journal of Nursing : BJN·Claire Camara
May 11, 2017·Journal of Paediatrics and Child Health·Jane BellNatasha Nassar
Oct 19, 2017·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Indrajit S KarandeThomas Snelling
Aug 3, 2016·International Journal of Clinical Pharmacy·Rou Wei Tan, Noraida Mohamed Shah
Sep 19, 2019·Pediatrics·Divya HoonDaniel B Horton

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