Clinical significance and diagnostic capacity of serum TK1, CEA, CA 19-9 and CA 72-4 levels in gastric and colorectal cancer patients

Journal of Cancer
Shufang NingLitu Zhang

Abstract

Despite extensive progress in treatment for cancer in recent decades, the early diagnosis for gastric cancer (GC) and colorectal cancer (CRC) remains poor. In this study, we explore the diagnostic value of joint detection of thymidine kinase 1 (TK1), carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA 19-9) and carbohydrate antigen 72-4 (CA 72-4) in the diagnosis of GC and CRC, and to evaluated the relationship between TK1 expression and clinical pathological characteristics in the patients. Serum TK1, CA 19-9, CA 72-4 and CEA levels were measured in 169 patients with GC, 344 patients with CRC and 75 healthy controls using electro-chemiluminescence. The TK1 concentration was significantly higher in patients with cancer than in healthy controls and patients with clinical stage Ⅲ+Ⅳ had higher TK1 levels than clinical stage Ⅰ+Ⅱ (P<0.05). The levels of TK1 is significantly associated with tumor stage, lymph node metastasis, distant metastasis, tumor differentiation and age (P<0.05). When the tumor markers (TK1, CA 19-9 and CA 72-4) were detected respectively, the area under receiver operating characteristics curve (AUC) of TK1 for three cancers was the highest (0.823-0.895). However, the combination of AUC was higher than...Continue Reading

Citations

Jul 23, 2019·Journal of Clinical Laboratory Analysis·Rongdan LuJunming Guo
Nov 14, 2019·Journal of Clinical Laboratory Analysis·Xiuchong YuJunming Guo
May 23, 2019·World Journal of Gastroenterology : WJG·Laura NeculaMihaela Chivu-Economescu
Jan 15, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·L X FengY Zhang
Mar 20, 2019·Journal of Cancer Research and Clinical Oncology·Jiejie QinJianying Zhang
Jun 21, 2019·Journal of Clinical Laboratory Analysis·Yu-Lei HouHui Chen
Apr 24, 2020·Cell Communication and Signaling : CCS·Wei ChenMei-Jin Huang
Oct 28, 2019·Frontiers in Oncology·Longhai LiYong Mao
Dec 10, 2020·Cell & Bioscience·Eliza E BitterKim L O'Neill
Jul 10, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Qian GongJinjin Wang
Jul 31, 2021·World Journal of Gastroenterology : WJG·Robert S O'Neill, Alina Stoita
Sep 2, 2021·International Journal of Clinical Practice·Hongyu LiuChong Zhang
Dec 4, 2021·World Journal of Surgical Oncology·Jian LvZhong Xin Li

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