Clinical Significance of 4L Lymph Node Dissection in Left Lung Cancer.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Ya-Nan WangZhen-Fa Zhang

Abstract

To investigate the prognostic impact of 4L lymph node (LN) dissection in left lung cancer and to analyze the relative risk factors for 4L LN metastasis. We retrospectively collected data from 657 patients with primary left lung cancer who underwent surgical pulmonary resection from January 2005 to December 2009. One hundred thirty-nine patients underwent 4L LN dissection (4LD+ group); the other 518 patients did not receive 4L LN dissection (4LD- group). Propensity score weighting was applied to reduce the effects of observed confounding between the two groups. Study end points were disease-free survival (DFS) and overall survival (OS). The metastasis rate of station 4L was 20.9%, which was significantly higher than those of station 7 (14.0%; P = .048) and station 9 (9.8%; P < .001). Station 4L metastasis was associated with most other LN station metastases in univariate analysis, but only station 10 LN metastasis was an independent risk factor for 4L LN metastasis (odds ratio, 0.253; 95% CI, 0.109 to 0.588; P = .001) in multivariate logistic analysis. The 4LD+ group had a significantly better survival than the 4LD- group (5-year DFS, 54.8% v 42.7%; P = .0376; 5-year OS, 58.9% v 47.2%; P = .0200). After allowing potential confou...Continue Reading

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Citations

Aug 28, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dirk K M De Ruysscher, Herbert Decaluwé
Mar 28, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Han-Yu DengXiaojun Tang
Mar 17, 2019·Journal of Cancer Research and Clinical Oncology·Likui FangJian Hu
Feb 6, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Mu-Zi YangHao-Xian Yang
Dec 29, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Haifeng ShenKezhong Chen
Jul 20, 2021·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Grzegorz M GryszkoUNKNOWN Polish Lung Cancer Study Group (PLCSG)
Aug 12, 2021·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Marco Lucchi, Vittorio Aprile
Aug 19, 2021·ANZ Journal of Surgery·Han-Yu DengQinghua Zhou

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