Clinical significance of acute and chronic ischaemic lesions in multiple cerebral vascular territories

European Radiology
Hebun ErdurChristian H Nolte

Abstract

To investigate the association between acute and chronic ischaemic lesions in a multiple territory lesion pattern (MTLP) detected by 3-Tesla MRI and stroke aetiology, specifically atrial fibrillation-associated stroke. We analysed data from the 1000+ study - a prospective, observational 3-Tesla MRI cohort study of consecutively included acute stroke patients. Acute and chronic lesions were detected by DWI and fluid-attenuated inversion recovery, respectively. Observers blinded to clinical data allocated lesions to the right anterior, left anterior or posterior circulation. Lesion pattern was categorised as MTLPa/c when more than one territory was affected by either acute or chronic lesions or as MTLPa when more than one territory was affected by acute lesions alone. Of the 1,000 included patients, an MTLPa/c was found in 43% and MTLPa in 24%. Advanced age (aOR=1.21 per 10 years, 95% CI 1.06-1.39), atrial fibrillation (aOR=1.44, 95% CI 1.06-1.94), aortic arch atherosclerosis (aOR=2.52, 95% CI 1.10-5.77), malignant disease (aOR=1.99, 95% CI 1.25-3.16) and lower estimated glomerular filtration rate (eGFR) (aOR=0.90 per 10 ml, 95% CI 0.84-0.97) were associated with MTLPa/c. Only malignant disease (aOR=2.03, 95% CI 1.27-3.23) and lo...Continue Reading

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Citations

Sep 21, 2019·Stroke; a Journal of Cerebral Circulation·Vojtech NovotnyNicola Logallo
May 14, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·William J PowersJason P Fine
Jun 19, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Renate B SchnabelKarl Georg Haeusler
Jul 2, 2021·Stroke; a Journal of Cerebral Circulation·Gregory W AlbersPeter Kowey
Aug 2, 2021·Brain and Behavior·Vojtech NovotnyNicola Logallo
Sep 28, 2021·International Journal of Stroke : Official Journal of the International Stroke Society·Ida Rangus Hebun Erdur

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