Clinical significance of ADAM29 promoting the invasion and growth of gastric cancer cells in vitro

Oncology Letters
Hongbing Chen, Siping Wang

Abstract

ADAM metallopeptidase domain 29 (ADAM29) belongs to the ADAM family, is a type I integral membrane protein and secrets a glycoprotein that mediates cell-cell and cell-matrix interaction. Aberrant expression of ADAM29 is involved in a number of physiological processes diversification. The purpose of the present study was to investigate the expression and biological effect of ADAM29 in human gastric cancer (GC) specimens and cell lines in vitro. The expression of ADAM29 was examined in 83 GC samples and 25 adjacent normal gastric tissues using quantitative reverse transcriptase-quantitative polymerase chain reaction and immunohistochemistry. The association between ADAM29 expression and cellular function of GC cells was assessed in vitro. The ADAM29 mRNA levels were significantly elevated in GC tissues compared with paracancerous tissues. Increased levels of ADAM29 were associated with high-grade staging and high Tumor-Node-Metastasis stages. Kaplan-Meier survival curves demonstrated that patients with GC and low ADAM29 transcript levels exhibited longer overall survival (OS) (P<0.01) and progression-free survival (PFS) time (P<0.01) compared with patients with high ADAM29 expression levels. ADAM29 significantly promoted the prol...Continue Reading

References

Oct 8, 1999·Biochemical and Biophysical Research Communications·D P CerrettiN Nelson
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Apr 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hélène Le PabicNathalie Théret
Jul 30, 2005·International Journal of Cancer. Journal International Du Cancer·Takashi OhtsukaYasunori Okada
Sep 3, 2008·Molecular Aspects of Medicine·Dylan R EdwardsCaroline J Pennington
Feb 4, 2010·PloS One·Hassan AshktorabHassan Brim
May 18, 2013·Biochimica Et Biophysica Acta·Erin K Nyren-EricksonSanku Mallik
Dec 10, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Robert V BrownTracy A Brooks
Jul 11, 2014·Breast Cancer Research and Treatment·Bo ZhangZhen-dong Chen
Jul 19, 2014·Cell·Han QinMiguel Ramalho-Santos
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Jul 16, 2015·PloS One·Renata Mężyk-KopećJoanna Bereta
Feb 13, 2016·Postȩpy higieny i medycyny doświadczalnej·Katarzyna WalkiewiczEwa Nowakowska-Zajdel
Feb 24, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yanfeng HuGuoxin Li
Aug 25, 2016·Biochimie·Kelli Cristina MicocciHeloisa Sobreiro Selistre-de-Araujo
Aug 3, 2017·Current Opinion in Gastroenterology·Shayan IraniMouen A Khashab

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Methods Mentioned

BETA
Transfection
protein assay

Software Mentioned

KMplot
ImageJ

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