Clinical Significance of Alloantibodies in Hand Transplantation: A Multicenter Study

Transplantation
Erik BerglundStefan Schneeberger

Abstract

Donor-specific antibodies (DSAs) have a strong negative correlation with long-term survival in solid organ transplantation. Although the clinical significance of DSA and antibody-mediated rejection (AMR) in upper extremity transplantation (UET) remains to be established, a growing number of single-center reports indicate their presence and potential clinical impact. We present a multicenter study assessing the occurrence and significance of alloantibodies in UET in reference to immunological parameters and functional outcome. Our study revealed a high prevalence and early development of de novo DSA and non-DSA (43%, the majority detected within the first 3 postoperative y). HLA class II mismatch correlated with antibody development, which in turn significantly correlated with the incidence of acute cellular rejection. Cellular rejections preceded antibody development in almost all cases. A strong correlation between DSA and graft survival or function cannot be statistically established at this early stage but a correlation with a lesser outcome seems to emerge. While the phenotype and true clinical effect of AMR remain to be better defined, the high prevalence of DSA and the correlation with acute rejection highlight the need f...Continue Reading

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Citations

Dec 24, 2019·International Journal of Immunogenetics·Daniel J WilksSimon P J Kay
Dec 17, 2019·International Journal of Immunogenetics·Brendan ClarkSimon P J Kay
May 30, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Stefan Schneeberger
Sep 25, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Theresa HautzStefan Schneeberger
Aug 31, 2021·Frontiers in Immunology·Dimitrios Moris, Linda C Cendales

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