Clinical significance of an elevated ankle-brachial index differs depending on the amount of appendicular muscle mass: the J-SHIPP and Nagahama studies

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Yasuharu TabaraJ-SHIPP and Nagahama study groups

Abstract

Clinical implication of a high ankle-brachial index (ABI) is not well known. Based on our previous study, we suspected that body composition may be a determinant of a high ABI and may consequently modulate the clinical significance of a high ABI. Datasets of two studies with independent cohorts, the anti-aging study cohort (n = 1765) and the Nagahama study cohort (n = 8,039), were analyzed in this study, in which appendicular muscle mass was measured by computed tomography and bioelectrical impedance analysis, respectively. Brachial and ankle blood pressures were measured using a cuff-oscillometric method. In the anti-aging study cohort, thigh muscle area (β = 0.387, p < 0.001), but not fat area, showed a strong positive association with the ABI independent of the body mass index (p = 0.662) and other possible covariates, including systolic brachial blood pressure (p = 0.054), carotid hypertrophy (p = 0.559), and arterial stiffness (β = 0.102, p = 0.001). This positive association was replicated in the Nagahama cohort. When the subjects were subdivided by the 75th percentiles of the ABI and appendicular muscle mass, multinomial logistic regression analysis identified insulin resistance as an independent determinant of an elevat...Continue Reading

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Feb 1, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yasuharu TabaraUNKNOWN and the Nagahama study group

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Citations

Jun 23, 2020·ESC Heart Failure·Jingjing ZhangHongcai Shang
Jun 12, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yukiko HigoUNKNOWN Nagahama study group
Mar 27, 2021·Atherosclerosis·Anna G HoekUNKNOWN SMART Study Group

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Methods Mentioned

BETA
X-ray
glycosylation

Software Mentioned

JMP
OsiriX

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