Clinical significance of atypical squamous cells of undetermined significance after treatment for cervical intraepithelial grade 3 neoplasia: A retrospective single-center cohort study

Molecular and Clinical Oncology
Toshimichi OnumaYoshio Yoshida

Abstract

The aim of the present study was to evaluate the clinical significance of atypical squamous cells of undetermined significance (ASC-US) following cervical conization for cervical intraepithelial neoplasia (CIN) grade 3. This study was a retrospective cohort analysis. The medical records of women treated with conization for CIN 2-3 were reviewed and 142 patients with CIN 3 who had been diagnosed using the conization specimens were selected. The mean follow-up period after conization was 41.8 months. Cytological abnormalities after conization were observed in 19.0% of the patients and consisted of ASC-US (13.4%) and worse than low-grade squamous intraepithelial lesion (LSIL; 5.6%). Recurrence was defined as a diagnosis worse than CIN 2, and the recurrence rate was 29.6% among patients with abnormal cytology. The recurrence rate was 15.7% in the ASC-US group and 71.4% in the worse than LSIL group. There was no significant difference in the time of initial identification of abnormal cytology after treatment between the worse than LSIL and the ASC-US groups (P=0.054). However, the ASC-US group had a significantly better cumulative recurrence-free rate compared with the worse than LSIL group (P<0.05). Women with ASC-US following trea...Continue Reading

References

Jan 1, 1991·Gynecologic Oncology·J V BrownD J Corwin
Jun 1, 1993·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P VedelE Bostofte
Apr 23, 2002·JAMA : the Journal of the American Medical Association·Diane SolomonUNKNOWN Bethesda 2001 Workshop
Oct 19, 2007·The New England Journal of Medicine·Marie-Hélène MayrandUNKNOWN Canadian Cervical Cancer Screening Trial Study Group
Sep 16, 2009·The Journal of Obstetrics and Gynaecology Research·Nan Hee JeongKyu Wan Lee
Sep 28, 2010·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P LeguevaqueJ Hoff
Apr 2, 2013·The Cochrane Database of Systematic Reviews·Marc ArbynWalter J Prendiville
May 3, 2013·Obstetrics and Gynecology·L Stewart MassadUNKNOWN 2012 ASCCP Consensus Guidelines Conference
Nov 23, 2013·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists
Oct 16, 2015·São Paulo Medical Journal = Revista Paulista De Medicina·Fanny López-AlegríaJuan Carlos Sepúlveda Oyanedel
Jan 9, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Mai NishimuraTakeshi Yokoi
Jul 2, 2016·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Laurențiu PirteaOctavian Mazilu
Sep 7, 2016·The Lancet Oncology·Sharon J B HanleyNoriaki Sakuragi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bowen's Disease

Bowen's disease is thought of as an easily-treatable early stage of skin cancer, characterized by red, scaly patches on the skin. Discover the latest research on Bowen's disease here.