PMID: 22200720Dec 28, 2011Paper

Clinical significance of blood and fecal tumor M2-pyruvate kinase expression in patients with colorectal cancer

Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Yong Li, Jun-jiang Wang


To evaluate the clinical significance of blood and fecal expression of tumor M2-pyruvate kinase (Tumor M2-PK) in patients with colorectal cancer. With 22 healthy subjects as controls, 44 patients with CRC were examined for tumor M2-PK in serum and fecal samples using a sandwich enzyme immunoassay. The sensitivity of serum and fecal tumor M2-PK for detecting CRC was 59.1% and 63.6% with a specificity of 86.4% and 81.8%, respectively. The serum and fecal levels of tumor M2-PK showed a significant correlation in CRC patients. Tumor M2-PK has good sensitivity and specificity in the diagnosis of CRC.

Related Concepts

R-Type Pyruvate Kinase
Tumor Markers
Colorectal Neoplasms
Nested Case-Control Studies
Drug Kinetics
M2-Type Pyruvate Kinase
Enzyme Immunoassay

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