Clinical significance of c-myc and p53 expression in head and neck squamous cell carcinomas

Cancer Detection and Prevention
Angela F L WaitzbergM M Brentani

Abstract

c-myc and p53 genes were frequently deregulated in head and neck squamous cell carcinoma (HNSCC). To determine if the concomitant expression of the two oncogenes might have prognostic value, the survival and free disease time of 140 consecutive HNSCC patients followed up for a median time of 29.9 months was analyzed in the light of p53 and c-myc expression assessed by immunohistochemistry. Positive c-myc and p53 staining was detected respectively in 35.7 and 50.7% of the tumors. Double positivity emerged in 16.4% of the cases. Overall-survival of patients was not associated with the immunoreactivity of p53 or c-myc considered separately or grouped in subsets. Considering only the advanced stages, the concomitant expression of both oncogenes in tumors was associated with worse disease-free survival (P = 0.004) suggesting a role for p53 and c-myc genes in progression of this HNSCC subset. Clinical parameters (presence of lymph nodes, histologic grade and tumor width) remained important indicators of overall survival (OS).

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Citations

May 10, 2012·Journal of Oncology·Maria J WorshamVanessa P Schweitzer
May 21, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·N BhattacharyaC K Panda
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Apr 27, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Govinda Raju YedidaRajakishore Mishra
Aug 12, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Neeraj SethiPamela Rabbitts
Jul 3, 2013·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·José de Assis Silva JúniorSimone Queiroz Chaves Lourenço
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Jan 24, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Federica GanciGiovanni Blandino
May 1, 2021·Microorganisms·Takuya NakagawaAtsushi Kaneda

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