Abstract
Enlarged cardiac silhouette on chest x-ray (CXR) in the absence of cardiopulmonary disease is often dismissed as "pseudocardiomegaly." We aimed to assess the impact of epicardial adipose tissue (EAT) on radiographic heart size and to determine the clinical significance of cardiomegaly caused by EAT. In total 112 patients (52 ± 13 years old, 53% women, body mass index 32 ± 8 kg/m(2)) with structurally normal hearts by transthoracic echocardiography underwent cardiac computed tomography (CCT). EAT volume was measured by CCT and cardiothoracic ratio (CTR) and cardiac transverse and lateral horizontal transverse diameters were measured on posteroanterior and lateral view CXR. EAT volume (mean 122 ± 49 ml) correlated directly with age, body mass index, hypertension, hyperlipidemia (p <0.05 for all comparisons), transverse diameter (r = 0.50, p <0.001), CTR (r = 0.45, p <0.001), and lateral horizontal transverse diameter (r = 0.38, p <0.001). EAT volume was larger in those with increased (n = 22) compared to those with normal (n = 90) CTR (154 ± 54 vs 115 ± 54 ml, p = 0.0005). Patients with cardiomegaly were also older (58 ± 13 vs 50 ± 12 years old, p = 0.009) and more often had diabetes (32% vs 9%, p = 0.03), hypertension (86% vs 46...Continue Reading
References
Jan 1, 1979·Circulation·K E HammermeisterH T Dodge
Oct 1, 1992·American Heart Journal·W H FrishmanM Aronson
Sep 15, 1986·The American Journal of Cardiology·J L DavisE J Ferris
Jul 1, 1988·The American Journal of Cardiology·P M RautaharjuJ Cornoni-Huntley
Dec 1, 1988·International Journal of Cardiology·Y JuillièreF Cherrier
Dec 23, 1971·The New England Journal of Medicine·P A McKeeW B Kannel
Aug 15, 1995·The American Journal of Cardiology·J ShiraniW C Roberts
Mar 1, 1995·Hypertension·V L BurtD Labarthe
Jul 4, 1998·European Heart Journal·L Wilhelmsen
Nov 7, 1998·BMJ : British Medical Journal·C Hart, G D Smith
Apr 25, 2000·Postgraduate Medical Journal·A L Clark, A J Coats
Dec 14, 2006·Heart·M Justin S ZamanHarry Hemingway
May 3, 2008·Obesity·Gianluca IacobellisArya M Sharma
Sep 9, 2008·The American Journal of Cardiology·Sanjay SarinJamshid Shirani
Oct 15, 2008·Hypertension·Jeffrey A CutlerEdward J Roccella
May 7, 2009·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Adam J NelsonStephen G Worthley
Apr 17, 2010·JACC. Cardiovascular Imaging·Victor Y ChengDaniel S Berman
Jul 22, 2010·Atherosclerosis·Sandra N Verhagen, Frank L J Visseren
Nov 13, 2010·JACC. Cardiovascular Imaging·Balaji TamarappooDaniel S Berman
Dec 28, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Matthew R NelsonR Todd Hurst