Clinical significance of circulating miR-122 in patients with dual chronic hepatitis B and C virus infection

Hepatology International
Huei-Ru ChengChun-Jen Liu

Abstract

The clinical significance of serum microRNA-122 (miR-122) has been shown in viral hepatitis B and C, respectively. Specifically, miR-122 stimulates hepatitis C virus (HCV) replication but suppresses hepatitis B virus (HBV) replication. The profile and clinical significance of serum miR-122 in patients with dual chronic hepatitis B and C would be an interesting and important clinical issue. A total of 76 patients with HBV/HCV dual infection, 105 with HCV monoinfection and 39 with HBV monoinfection were enrolled. All patients received peginterferon alfa-2a (PEG-IFN)-based treatment. Serum miR-122 levels were quantified by using a sensitive hybridization-based assay. At baseline, the serum miR-122 level was lower in HCV-monoinfected patients than in HBV-monoinfected patients, whereas HBV coinfection increased the expression of miR-122. In multivariate analysis, the serum miR-122 level was positively correlated with the serum HBsAg level in patients with HBV/HCV dual infection and those with HBV monoinfection. In dually infected patients who received PEG-IFN-based treatment, a high baseline miR-122 level was positively correlated with a greater reduction of the posttreatment serum HBsAg level. In summary, the serum miR-122 level is...Continue Reading

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Apr 10, 2016·Journal of Digestive Diseases·Weijing WangQing Xie
Aug 2, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna S LokMarc G Ghany
Nov 30, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Wendy J BaileyWarren E Glaab

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