PMID: 7543167Jul 1, 1995Paper

Clinical significance of circulating soluble E-selectin (ELAM-1) in patients with cancers

Nihon rinsho. Japanese journal of clinical medicine
C Mitsuoka, R Kannagi

Abstract

Cell adhesion mediated by E-selectin and its carbohydrate ligands, Le(a) and Le(x), plays an important role in cancer metastasis. We determined soluble E-selectin concentration in the sera of patients with cancers using double determinant sandwich assay. The results indicated that the patients with metastatic colon cancers had significantly higher serum E-selectin concentration than the patients having no metastatic lesion. The highest frequency of metastasis was obtained in Le(a) HIGH E-selectinHIGH patients (80%), while the frequency was quite low in Le(a) LOW E-selectinLOW patients (17%). Expression of E-selectin, as well as its carbohydrate ligands, is suggested to be a risk factor for the metastasis of epithelial cancers. Soluble E-selectin-carbohydrate complex was also detected in the sera of patients, and the frequency was especially high in Le(a) HIGH E-selectinHIGH patients.

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.