PMID: 9555971Apr 29, 1998Paper

Clinical significance of CSF glutamate concentrations following severe traumatic brain injury in humans

Journal of Neurotrauma
J I BrownR J Moulton

Abstract

Glutamate excitotoxicity is a putative mechanism of secondary damage after traumatic brain injury (TBI). No relationship between glutamate release and clinical status has been shown in humans, however. We hypothesize a dose-response relationship between CSF glutamate concentrations and severity of injury, electrophysiological deterioration as measured by somatosensory evoked potential amplitudes, and clinical outcome. From August 1991 to March 1996, intensive monitoring of 55 patients with severe TBI (GCS < or = 8 after resuscitation) included twice daily CSF glutamate levels and hourly somatosensory evoked potentials (SSEPs) for an average of 5 days. Clinical outcomes were survival/nonsurvival and Glasgow outcome score (GOS) at 3 months or more post-injury. Glutamate levels were not associated with severity of injury, electrophysiological deterioration, or clinical outcome. Neither peak nor mean glutamate levels significantly improved a simple logistic regression model which used only age and presence of bilaterally unreactive pupils to predict survival. Using this methodology CSF glutamate concentrations did not display a dose-response relationship to severity of injury, electrophysiological deterioration, or predict clinical...Continue Reading

References

May 15, 1976·Lancet·B JennettR Knill-Jones
Mar 1, 1977·Journal of Neurology, Neurosurgery, and Psychiatry·B JennettT Kurze
Jan 1, 1992·Trends in Pharmacological Sciences·A I Faden, S Salzman
Jan 1, 1990·Pediatric Neurosurgery·P M SheddenP J Muller
Dec 1, 1988·Annals of Neurology·R N Auer, B K Siesjö
Jul 1, 1986·Journal of Neurosurgery·D M LyleJ M Grant
Apr 1, 1995·Journal of Neurosurgical Anesthesiology·M H Zornow
Sep 1, 1994·The Journal of Trauma·S J Konasiewicz, R J Moulton
Sep 1, 1993·Neuron·D AttwellM Szatkowski
Oct 1, 1995·Journal of Neurotrauma·C S RobertsonR K Narayan

❮ Previous
Next ❯

Citations

Nov 15, 2000·Hippocampus·F M Smart, S Halpain
May 23, 2001·Progress in Neurobiology·N C Danbolt
Jan 30, 2004·Journal of Neurotrauma·Mark ArundineMichael Tymianski
Sep 26, 2002·Journal of Neurosurgery·Alois ZaunerRoss Bullock
Sep 3, 2011·Surgical Neurology International·Russell L Blaylock, Joseph Maroon
Apr 22, 2015·Journal of Neurotrauma·F Anthony WillyerdRobert S B Clark
Dec 5, 2009·European Journal of Pharmacology·Amos AdeleyeAnat Biegon
Nov 4, 2015·Frontiers in Behavioral Neuroscience·Vanessa M DoulamesThomas B Shea
Mar 23, 2011·British Journal of Pharmacology·Esther ShohamiRaphael Mechoulam
Jun 23, 2015·Journal of Neurochemistry·Andréia C K Fontana
Jun 24, 2006·Brain Research·Beata ToczyłowskaEwa Mayzner-Zawadzk
Dec 27, 2005·The Veterinary Journal·Simon R Platt
Oct 9, 2004·Journal of Vascular Surgery·Takashi KuniharaKeishu Yasuda
Jun 6, 2016·World Neurosurgery·Leonardo C WellingEberval Gadelha Figueiredo
Jun 2, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·William M Armstead
Mar 10, 2001·The Journal of Trauma·J A DoyleD B Hoyt
Jun 19, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Patrick M. KochanekLarry W. Jenkins
Apr 13, 2018·Journal of Neurotrauma·Sigal Liraz-ZaltsmanEsther Shohami
Mar 10, 2000·Journal of Neurotrauma·T ChenR Bullock
Aug 18, 2006·The Journal of Head Trauma Rehabilitation·Lori ShutterBarbara A Holshouser
Oct 3, 2006·Current Opinion in Anaesthesiology·D K Menon, A C Summors
Jun 8, 2017·Annals of Clinical and Translational Neurology·Marco A StefaniLuis V Portela
Feb 25, 2021·Neuro-oncology·Huimin GengJames L Rubenstein
Nov 16, 2017·ACS Chemical Neuroscience·Sandhya KortagereAndréia C K Fontana
Apr 29, 2020·ACS Chemical Neuroscience·Yvonne M ForsterAndréia Cristina Karklin Fontana
Jul 2, 2019·ACS Chemical Neuroscience·Romulo Martelli FalcucciAndréia Cristina Karklin Fontana

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.