PMID: 19923094Nov 20, 2009Paper

Clinical significance of detecting serum erythropoietin in patients with leukemia

Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Na Su, Jin Liu

Abstract

To detect serum erythropoietin (EPO) levels in patients with acute leukemia (AL) and iron deficient anemia (IDA) with moderate or severe anemia and explore the mechanism of anemia in these patients. Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum levels of EPO in 59 patients with AL, among whom 15 had complete remission without anemia and 44 had moderate or severe anemia (including 12 receiving the initial treatment, 13 with complete remission and concurrent anemia, and 19 with bone marrow suppression). Serum EPO was also detected in 15 IDA patients and 12 healthy individuals. The IDA patients and healthy individuals had similar serum EPO levels (P>0.05), and by comparison, the EPO levels were significantly increased in AL patients upon the initial treatment, those with bone marrow suppression and those with complete remission and anemia, but comparable between the latter 3 groups (P>0.05). Among the patients with complete remission, the EPO levels were significantly higher in anemic patients than in those without anemia (P<0.05), and the latter patients had similar EPO levels with the healthy individuals (P>0.05). In both AL and IDA patients with moderate or severe anemia, the serum EPO level was inverse...Continue Reading

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