Clinical significance of different virus load of human bocavirus in patients with lower respiratory tract infection

Scientific Reports
Wujun JiangWei Ji

Abstract

To assess the impact of human bocavirus (HBoV) virus load on epidemiologic and clinical characteristics in children with lower respiratory tract infection (LRTI). Clinical records of a total of 654 patients with HBoV infection during January 2013 and December 2014 were retrospectively reviewed. Patients with high HBoV virus load infection had a similar age distribution with the total HBoV infection, which had a peak age group of 6-24 months. Patients with high virus load are significantly younger (P < 0.01) than those with low load. The patients who had wheeze and tachypnea/dyspnea at presentation were more strongly affiliated with the patients with high virus load (both P < 0.01). Co-infection was found significantly more frequently among patients with low virus load than those with high virus load (57.0% vs 38.9%; P < 0.01). High virus load was a significant predictor of severe LRTI (P < 0.05). HBoV infections are found in an important proportion of the hospitalized children with respiratory illnesses (8.85% in our series). A high HBoV virus load could be an etiologic agent for LRTI, which may lead to more severe lower respiratory tract symptom and severe disease.

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Citations

Nov 4, 2016·Clinical Microbiology Reviews·Jianming QiuNeal S Young
May 31, 2019·Acta Microbiologica Et Immunologica Hungarica·Mehrdad MohammadiNafiseh Sadat Hosseini
Oct 8, 2019·Internal Medicine·Takashi IshiguroNoboru Takayanagi
Sep 16, 2019·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Mehrdad MohammadiZahra Yazdanpour
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Jul 5, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Han Na LeeKyung Hyun Do
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Sep 12, 2018·Journal of Tropical Pediatrics·Huiming SunYuqing Wang
Nov 4, 2016·Food and Environmental Virology·M IaconelliGiuseppina La Rosa
Sep 14, 2018·Experimental and Therapeutic Medicine·Lin ZhangChunbin Wang

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Methods Mentioned

BETA
PCR
enzyme-linked immunosorbent assay

Software Mentioned

Statistical Package for the Social Sciences ( SPSS

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