Clinical significance of elevated serum and urine amylase levels in patients with appendicitis

American Journal of Surgery
E E Swensson, K I Maull

Abstract

During the 45 month period beginning January 1977, 251 patients with a pathologically confirmed diagnosis of acute appendicitis underwent celiotomy at the Medical College of Virginia Hospital. A preoperative serum or urine amylase determination was recorded in 155 of the patients (62 percent). Of this group, 15 patients (10 percent) had elevation of serum amylase or 2 hour urine amylase. Hyperamylasemia or hyperamylasuria directly led to misdiagnosis or treatment delay in 5 of the 15 patients. Appendiceal rupture occurred in three patients, two of whom had prolonged (greater than 1 month) hospitalizations directly attributable to the misdiagnosis. As a result of this study, we conclude that (1) acute appendicitis and elevated amylase levels may occur concurrently, (2) hyperamylasemia or hyperamylasuria should not dissuade the surgeon from early operation if other clinical features suggest appendicitis, and (3) abdominal pain and elevation of amylase level define significant intraabdominal disease, not specifically pancreatic disease.

References

Jul 1, 1976·Medicine·W B Salt, S Schenker
Jan 1, 1967·Annals of Surgery·J E Trapnell, M C Anderson
Sep 24, 1955·British Medical Journal·W BURNETT, T D NESS
Jun 1, 1958·Archives of Biochemistry and Biophysics·R L McGEACHINM R ADAMS
Jul 1, 1961·Archives of Surgery·D W ELLIOTT, R D WILLIAMS
Aug 1, 1951·Annals of Internal Medicine·E C RAFFENSPERGER

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Citations

Jun 1, 1987·Digestive Diseases and Sciences·D M JensenJ Schaffner
Apr 1, 1989·Digestive Diseases and Sciences·A Borgström, M Bohe
Apr 5, 2011·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Raffaele PezzilliGianvico Melzi d'Eril
Mar 20, 2008·World Journal of Gastroenterology : WJG·Michael-J Forster, Jacob-A Akoh
Jan 15, 2008·Lancet·Jean-Louis FrossardCatherine M Pastor
May 1, 1985·Annals of Emergency Medicine·E E SwenssonK I Maull
Dec 3, 2015·Archives of Disease in Childhood. Education and Practice Edition·Giorgio CozziEgidio Barbi
Sep 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lionel LimTrevor Leong
Jan 1, 1989·Archives of Oto-rhino-laryngology·H F Mahieu, H K Schutte
Mar 13, 2014·Journal of Pediatric Gastroenterology and Nutrition·Maisam Abu-El-HaijaJoseph Palermo

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