PMID: 19122348Jan 6, 2009Paper

Clinical significance of extrathyroid extension to the parathyroid gland of papillary thyroid carcinoma

Endocrine Journal
Yasuhiro ItoAkira Miyauchi

Abstract

Extrathyroid extension is a prominent prognostic factor of papillary thyroid carcinoma (PTC). In the UICC TNM classification, minimal extension to the sternothyroid muscle and perithyroid soft tissue is classified as T3 and further massive extension is classified as T4, the highest T grade. However, there have been few studies on the clinical significance of extension to the parathyroid gland in a large case series. In this study, we investigated the prognosis of PTC with extension to the parathyroid gland in a series of 3208 patients who underwent initial surgery between 1997 and 2004. Of these patients, 51 (1.6%) showed extension to the parathyroid gland on pathological examination. Twenty-one of these patients had massive extrathyroid extension to other adjacent organs corresponding to pT4. The remaining 30 were enrolled in this study. The disease-free survival (DFS) of these 30 patients was significantly better (p<0.0001) than that of pT4 patients and did not differ from that of patients showing minimal extrathyroid extension without extension to the parathyroid gland (p = 0.6264). Furthermore, none of these 30 patients died of carcinoma. Taken together, it is appropriate that extension to the parathyroid gland of PTC is gr...Continue Reading

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Dec 17, 2008·Surgery·Yasuhiro ItoAkira Miyauchi

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Citations

Dec 2, 2009·Annals of Surgical Oncology·Ozgur MeteSylvia L Asa
Jun 30, 2012·World Journal of Surgical Oncology·Alexandra ChrisoulidouKalliopi Pazaitou-Panayiotou
Oct 25, 2016·The Lancet. Diabetes & Endocrinology·Jena D FrenchMabel Ryder
Sep 7, 2017·Head and Neck Pathology·Justin L BauerLester D R Thompson
Sep 17, 2020·Cancers·Cristina Alina SilaghiCarmen Emanuela Georgescu

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