Clinical significance of fibroblast growth factor receptor 2 expression in patients with residual rectal cancer after preoperative chemoradiotherapy: relationship with KRAS or BRAF mutations and MSI status

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Ghilsuk YoonAn Na Seo

Abstract

This study was designed to determine the prognostic impact and clinical significance of FGFR2 in residual disease after preoperative chemoradiotherapy (CRT) in patients with rectal cancer. The surgical specimens of 145 patients with residual rectal cancer after preoperative CRT were analyzed. To evaluate FGFR2 expression, immunohistochemistry was performed on whole section tissues. KRAS exon 2 (codon 12 and 13), BRAF V600E mutational status, and microsatellite instability (MSI) were determined using polymerase chain reactions. Of the eligible 141 patients, FGFR2 over-expression was observed in 75.9 % (n = 107) and was correlated with perineural invasion (P = 0.005) and inferior tumor regression grading (TRG) (P = 0.009). However, FGFR2 expression had no relationship with KRAS and BRAF mutation results or with MSI results. On univariate analysis, FGFR2 over-expression was significantly associated with worse rectal cancer-specific survival (RCSS) (P = 0.005) and disease-free survival (DFS) (P = 0.035). However, multivariate analysis revealed that FGFR2 over-expression was not independently associated with RCSS and DFS (all P > 0.05). Although FGFR2 over-expression did not independently influence patient outcome, FGFR2 over-expres...Continue Reading

References

Oct 22, 2004·The New England Journal of Medicine·Rolf SauerUNKNOWN German Rectal Cancer Study Group
Oct 26, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claus RödelChristian Wittekind
May 29, 2007·Nature·Douglas F EastonBruce A J Ponder
Oct 24, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Katsunobu SakuraiKosei Hirakawa
Feb 27, 2009·Future Oncology·Sara A Byron, Pamela M Pollock
Jan 23, 2010·Nature Reviews. Cancer·Nicholas Turner, Richard Grose
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Jul 5, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sonia GatiusXavier Matias-Guiu
Apr 25, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rolf SauerClaus Rödel
Jul 11, 2012·Molecular Cancer Therapeutics·Yoko MatsudaToshiyuki Ishiwata
Aug 23, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Anne RullierJean-Pierre Gérard
Mar 16, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Liang XieQunsheng Ji
Aug 5, 2014·Virchows Archiv : an International Journal of Pathology·An Na SeoJin-Haeng Chung
Mar 6, 2015·Virchows Archiv : an International Journal of Pathology·An Na SeoHye Seung Lee
Aug 22, 2015·Molecular Cancer Therapeutics·Yeonui KwakTaebo Sim
Oct 13, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ghilsuk YoonAn Na Seo

❮ Previous
Next ❯

Citations

Oct 7, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Catherine ZilbergRuta Gupta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Ghilsuk YoonAn Na Seo
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Claus RödelChristian Wittekind
Annals of Oncology : Official Journal of the European Society for Medical Oncology
A Fariña-SarasquetaA J C van den Brule
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Amanda I PhippsPolly A Newcomb
© 2021 Meta ULC. All rights reserved