Clinical significance of galectin-7 in vulvar squamous cell carcinoma

Oncology Letters
Ying JiangXin Wu

Abstract

The present study reports the role of galectin-7 (Gal-7) expression in vulvar squamous cell carcinoma (VSCC) and its correlation with clinicopathological variables. Gal-7 expression was immunohistochemically detected in the paraffin-embedded sections of 20 normal vulvar biopsy samples and 50 VSCC specimens. Expression was also detected in 10 normal vulvar biopsy samples and 10 VSCC specimens by western blotting. In addition, the methylation status of the promoter of the Gal-7 gene was determined in 30 VSCC specimens and 20 samples of normal vulvar tissue by methylation-specific polymerase chain reaction. Gal-7 expression was found to be significantly downregulated in the VSCC tissues compared with the normal vulvar tissues (P<0.05). Downregulation of Gal-7 was correlated with advanced clinical stage, poor tumor differentiation and regional lymph node metastasis (P<0.05). Furthermore, methylation of the Gal-7 gene promoter was significantly reduced in the vulvar normal tissues compared with the VSCC tissues (P=0.023), while increased Gal-7 promoter methylation was correlated with advanced clinical stage, poor tumor differentiation and regional lymph node metastasis (P<0.05). There was no association between patient age and Gal-7...Continue Reading

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Citations

Sep 20, 2016·Disease Markers·Vlad VoiculescuConstantin Caruntu
Dec 20, 2017·International Journal of Molecular Sciences·Tamara AdvedissianMireille Viguier
Jul 7, 2020·Integrative Zoology·Jing TianShunying Zhao
Jan 12, 2021·International Journal of Cancer. Journal International Du Cancer·Nikki B ThuijsMaaike C G Bleeker

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Methods Mentioned

BETA
PCR
biopsies
glycosylation

Software Mentioned

MetaMorph
Quantity One
SPSS

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