Clinical Significance of Has_circ_0060937 in Bone Metastasis of NSCLC

International Journal of General Medicine
Jiangnan ZhangChan Lian

Abstract

Bone metastasis can induce multiple types of bone diseases which reduce the non-small-cell lung cancer (NSCLC) patient's quality-of-life. Due to the difficulty of finding bone metastases and lack of effective early diagnosis, it is easy to miss the best treatment. Therefore, the study of serum tumor biomarkers is of great significance in the diagnosis of NSCLC bone metastasis. The qRT-PCR assay was performed to assess has_circ_0060937 expression in 100 NSCLC patients. Furthermore, the small interfering RNAs si-has_circ_0060937 or si-NC were transfected into NSCLC bone metastasis cells. CCK8 assay was exercised to detect cell proliferation, and cell invasion assays were used to detect cell invasion in NSCLC bone metastasis cells. In this study, we firstly found that the expression of has_circ_0060937 in boneless metastasis NSCLC tissues and bone metastasis NSCLC tissues was significantly increased compared to normal tissues, and the expression of has_circ_0060937 was highest in bone metastasis. Expression of serum has_circ_0060937 in bone metastasis group from Grade I to Grade III NSCLC was drastically higher than boneless metastasis group or healthy group. In the Grade I to Grade III bone metastasis group, the expression of ser...Continue Reading

References

Feb 15, 2002·Respiration; International Review of Thoracic Diseases·Kostas D HatzakisNikolaos M Siafakas
Jan 26, 2018·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Lois A DaamenI Quintus Molenaar
Nov 20, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Chenxing ZhangHaiyong Wang
Jan 29, 2019·Cancer Biomarkers : Section a of Disease Markers·Juan WeiWei De
Jul 23, 2019·Journal of Clinical Laboratory Analysis·Rongdan LuJunming Guo
Aug 30, 2019·Science China. Life Sciences·Zijie Cai, Qiang Liu
Nov 14, 2019·Journal of Clinical Laboratory Analysis·Xiuchong YuJunming Guo
Jan 9, 2020·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 17, 2020·Journal of Clinical Laboratory Analysis·Suiju Tong
May 10, 2020·Molecular and Cellular Biochemistry·Yonghui TianJingjing Fu
Jun 5, 2020·Scientific Reports·Zhi-Ye ZhangShuang-Shuang Guo
Jul 17, 2020·JCO Global Oncology·Prashant MathurUNKNOWN ICMR-NCDIR-NCRP Investigator Group

❮ Previous
Next ❯

Citations

Jun 18, 2021·Frontiers in Molecular Biosciences·Lanxiang HuangFubing Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

SPSS
GEO2R
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.