PMID: 9438537Jan 23, 1998Paper

Clinical significance of hepatitis GB virus C infection in alcoholic liver disease

Alcoholism, Clinical and Experimental Research
M TsutsumiH Kawahara

Abstract

Recently, hepatitis GB virus C (HGBV-C) has been recovered from patients with non-A-E hepatitis. However, it has been unclear whether HGBV-C may be related to the development of alcoholic liver disease (ALD) or not. In this study, we determined HGBV-C RNA in sera from alcoholic patients without markers for hepatitis C and B viruses to evaluate the role of HGBV-C in ALD. Serum samples were obtained from 68 patients with ALD and 40 nonalcoholic patients with chronic type C liver disease. HGBV-C RNA was detected in only 3 of 68 (4.4%) patients with ALD, in 2 of 27 patients with hepatic fibrosis, and in 1 of 5 patients with chronic hepatitis. There was no HGBV-C RNA in sera from patients with fatty liver, alcoholic hepatitis, or cirrhosis. Serum levels of AST, ALT, and gamma-glutamyltranspeptidase in alcoholic patients with, as well as without, HGBV-C RNA decreased to normal levels after abstinence. In addition, an inflammatory change was not observed in liver biopsy specimens obtained from two HGBV-C-positive patients with alcoholic hepatic fibrosis. Our results clearly suggest that the prevalence of HGBV-C infection in patients with ALD is rare and that HGBV-C may not play an important role in the development of liver disease in ...Continue Reading

References

Dec 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A ParésJ Rodés
Jun 1, 1995·Nature Medicine·J N SimonsI K Mushahwar
Jun 6, 1996·The New England Journal of Medicine·H J Alter
Sep 1, 1995·Journal of Gastroenterology and Hepatology·A Takada, M Tsutsumi
May 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S M LemonL Johnson

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Citations

Jun 19, 2001·Alcoholism, Clinical and Experimental Research·M Tsutsumi And, S Takase

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