Clinical significance of histologic subtyping of malignant pleural mesothelioma

Translational Lung Cancer Research
Luka Brcic, Izidor Kern

Abstract

Malignant mesothelioma (MM) is uncommon, but very aggressive tumor arising from the mesothelial cells of pleura, pericardium, peritoneum, and tunica vaginalis. Despite multimodality treatments 5-year survival is only 5% after the diagnosis. Histology and TNM staging system are still the best prognostic factors. Furthermore, histologic subtype of MM determines the clinical management of the patients. According to the 2015 WHO classification, MM is divided into diffuse, localized and well differentiated papillary mesothelioma. Major histologic subtypes of diffuse MM, namely epithelioid, biphasic and sarcomatoid, have different prognosis. However, in the last decade it has become evident that more detailed subclassification and histologic/cytological characterization of MM have prognostic and perhaps predictive implications. In this review, major histologic subtypes and cytological features of MM are presented and their relation with prognosis and predictive biomarkers is discussed.

Citations

May 1, 2021·International Journal of Molecular Sciences·Silvia MolaChiara Porta
May 4, 2021·International Journal of Surgical Pathology·Diana M OramasCesar A Moran
Jun 3, 2021·Journal of Clinical Medicine·Amedeo IaffaldanoLudovic Fournel
Jul 28, 2021·Acta Oncologica·Odd Terje BrustugunInger Johanne Zwicky Eide
Aug 4, 2021·Abdominal Radiology·Isha D AtreMukesh G Harisinghani
Nov 19, 2021·Interactive Cardiovascular and Thoracic Surgery·Paola CiriacoGiampiero Negri

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