Clinical Significance of HMGB-1 and TGF-β Level in Serum and BALF of Advanced Non-Small Cell Lung Cancer

Advances in Experimental Medicine and Biology
K JakubowskaE Chyczewska

Abstract

Lung cancer is associated with poor prognosis. The aim of this study was to evaluate the clinical usefulness of HMGB-1 (high-mobility group protein B1) and TGF-β (transforming growth factor beta) in patients with advanced non-small cell lung cancer (NSCLC). We studied 45 patients with NSCLC prior to chemotherapy, 23 patients with Besnier-Boeck-Schaumann (BBS) disease (sarcoidosis), and 15 healthy volunteers. HMGB-1 and TGF-β levels were measured in serum and BALF samples using ELISA method. A higher serum HMGB-1 and TGF-β levels were in NSCLC patients compared with the other groups. TGF-β concentration in BALF was significantly higher in NSCLC than in healthy controls (p=0.047) but lower than in BBS (p=0.016). Serum HMGB-1 in NSCLC correlated with age and gender while its level in BALF was associated with distant metastasis. A higher levels of HMGB-1 in the serum of NSCLC patients with progressive disease was linked with shorter overall survival and disease-free survival. We found a positive correlation between HMGB-1 and TGF-β in BALF of IIIB NSCLC group and overall survival (p=0.04; p=0.003). Our findings confirmed that the measurement of HMGB-1 and TGF-β levels in serum and BALF of patients with NSCLC prior to treatment may ...Continue Reading

Citations

Sep 7, 2016·Vaccines·Saskia J A M SantegoetsSjoerd H van der Burg
Apr 18, 2018·Journal of Cellular Biochemistry·Xiao-Jin WuDong-Sheng Pei
Jun 20, 2019·Current Drug Targets·Eyaldeva C VijayakumarKedar S Prabhavalkar
Dec 24, 2019·Expert Review of Respiratory Medicine·Joanna Domagala-Kulawik
Dec 24, 2016·The International Journal of Biological Markers·Rong BiaoxueGao Wenlong
Mar 1, 2019·Cancers·Shang-Gin WuJin-Yuan Shih
Aug 6, 2019·Frontiers in Immunology·Carolina M GorgulhoMichael T Lotze
Jan 10, 2019·International Journal of Environmental Research and Public Health·Zhiyuan ChengKehu Yang
Jan 5, 2021·Cancer Immunology, Immunotherapy : CII·Pascal BezelDaniel P Franzen

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