Clinical significance of homocysteine in elderly hospitalized patients

Metabolism: Clinical and Experimental
José Juan Viña RodríguezMelchor Rodríguez Gaspar

Abstract

Serum homocysteine levels, which increase with age, are now recognized as a vascular risk factor and are related to the development of heart failure and dementia in the elderly. However, relatively low serum homocysteine levels have also been reported to be an adverse prognostic factor in dialysis patients. The objective of the study was to analyze the prevalence, clinical significance, and prognostic value of serum homocysteine levels in patients older than 65 years, admitted to a general internal medicine hospitalization unit. We studied 337 hospitalized patients, 184 males and 153 females, aged 77.2+/-0.4 years, whose admission was not determined by an acute vascular event. We recorded past vascular events and vascular risk factors. We determined the body mass index (weight in kilograms divided by the square of height in meters), and cholesterol, triglyceride, folate, vitamin B12, and homocysteine levels. We also studied 36 control subjects (18 males and 18 females) of similar age. After discharge, we assessed the survival status of 301 patients by telephone recall. Survival curves were plotted by the method of Kaplan and Meier. Median survival was 1186 days. The 15th (9.6 micromol/L) and 50th (14.4 micromol/L) percentiles, ...Continue Reading

References

Jan 1, 1977·JPEN. Journal of Parenteral and Enteral Nutrition·G L BlackburnM F Smith
Feb 2, 1995·The New England Journal of Medicine·J SelhubI H Rosenberg
Jun 2, 1998·Kidney International·A VychytilG Sunder-Plassmann
Oct 8, 1998·Seminars in Thrombosis and Hemostasis·G M Bos, M den Heijer
Apr 8, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S SirrsA Levin
Jun 11, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·R C CookA P Ignaszewski
Mar 25, 2000·The American Journal of Clinical Nutrition·S E VollsetP M Ueland
Dec 6, 2001·Metabolism: Clinical and Experimental·P VenturaG Salvioli
Feb 6, 2002·Nutrition·Yves IngenbleekLouis Jung
Oct 26, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN Homocysteine Studies Collaboration
Oct 24, 2002·Journal of Clinical Epidemiology·Leonelo E BautistaLuz X Martínez
Mar 4, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mohamed E SulimanBengt Lindholm
Mar 13, 2003·Kidney International·Kamyar Kalantar-ZadehJoel D Kopple
Mar 14, 2003·JAMA : the Journal of the American Medical Association·Ramachandran S VasanPeter W F Wilson
Oct 29, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kamyar Kalantar-ZadehJoel D Kopple
Jan 30, 2004·Journal of the American Society of Nephrology : JASN·Kamyar Kalantar-ZadehJoel D Kopple
Apr 20, 2004·Journal of the American College of Cardiology·Kamyar Kalantar-ZadehGregg C Fonarow
Jun 23, 2004·Archives of Gerontology and Geriatrics. Supplement·G RavagliaM Bianchin
Jul 29, 2004·Metabolism: Clinical and Experimental·Alessandra MarengoniVittorio Grassi
Aug 28, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mohamed E SulimanBengt Lindholm
Dec 10, 2008·The American Journal of Clinical Nutrition·Christian S ShinabergerKamyar Kalantar-Zadeh

❮ Previous
Next ❯

Citations

Dec 19, 2006·European Journal of Heart Failure·Raymond L C VogelsHenry C Weinstein
Sep 4, 2016·Journal of Intensive Care Medicine·Orren WexlerAnthony P Pietropaoli
Sep 17, 2020·Immunity·Aileen H Lee, Vishwa Deep Dixit

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.