Clinical significance of hypoalbuminemia in outcome of patients with scrub typhus.

BMC Infectious Diseases
Chang-Seop LeeHeung-Bum Lee

Abstract

This study was designed to investigate the clinical significance of hypoalbuminemia as a marker of severity and mortality in patients with Scrub typhus. The patients with scrub typhus were divided into two groups based on the serum albumin levels; Group I (serum albumin <3.0 g/dL) and Group II (serum albumin >or=3.0 g/dL). The outcome of patients with hypoalbuminemia was compared with that of normoalbuminemia. Of the total 246 patients who underwent the study, 84 patients (34.1%) were categorized as Group I and 162 patients were (65.9%) as Group II. Group I showed significantly higher incidence of confusion (24.6% vs. 5.3%, p < 0.001), pulmonary edema (15.8% vs. 3.2%, p = 0.002), pleural effusion (22.8% vs. 11.1%, p = 0.03), arrhythmia (12.3% vs. 2.6%, p = 0.008) and non-oliguric acute renal failure (40.4% vs. 11.1%, p < 0.001) compared to group II. Hypoalbuminemic group had a higher APACHE II score (11.37 +/- 5.0 vs. 6.94 +/- 4.2, p < 0.001), longer hospital stay (19.9 +/- 42.1 days vs 7.5 +/- 13.8 days, p = 0.012), and higher hospital cost compared to Group II. This study showed hypoalbuminemia in scrub typhus was closely related to the frequency of various complication, longer hospital stay, consequently the higher medical c...Continue Reading

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Citations

Jun 27, 2013·PloS One·Stalin ViswanathanTarun George
Nov 4, 2011·The American Journal of Tropical Medicine and Hygiene·Sang-Won ParkMyoung-don Oh
Jun 12, 2016·BMC Infectious Diseases·Hyung Ho KimMi Ah Han
Oct 5, 2016·Journal of Tropical Pediatrics·Dongying ZhaoQun Zhou
Feb 22, 2012·Journal of Infection and Public Health·Manish KumarSadagopan Srinivasan
Nov 6, 2015·Journal of Korean Medical Science·Hyun LeeChang-Seop Lee
Sep 15, 2012·Internal Medicine·Yirong FangBao-Ping Zhu
Sep 16, 2016·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Jyoti Narayan SahooYogesh Harde
Aug 31, 2020·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Karthi NallasamyAbhay Kumar

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