PMID: 19134330Jan 13, 2009Paper

Clinical significance of hypoxia inducible factor-prolyl hydroxylase 1 and factor inhibiting hypoxia inducible factor-1 expression in placentas of women with severe pre-eclampsia

Zhonghua fu chan ke za zhi
Nan-nan LuanTao Shang

Abstract

To investigate the role of hypoxia inducible factor (HIF)-prolyl hydroxylase 1 (HPH1) and factor inhibiting HIF-1 (FIH-1) in placentas in the pathogenesis and development of severe pre-eclampsia. RT-PCR and western blot analyses were used to detect the HPH1 and FIH-1 expression levels in placentas of 34 patients with severe pre-eclampsia and 24 cases of term pregnancy (normal pregnancy group) and their correlations with symptoms were analyzed. (1) The HPH1 mRNA and protein expression levels in placentas of severe pre-eclampsia group were 0.40 +/- 0.04 and 59.5 +/- 3.4 separately, significantly lower than those of normal pregnancy group, 0.84 +/- 0.12 and 71.6 +/- 1.7 (P < 0.01). The FIH-1 mRNA and protein expression levels in placentas of severe pre-eclampsia group were 0.31 +/- 0.05 and 45.6 +/- 2.4 separately, significantly lower than those of normal pregnancy group, 0.43 +/- 0.04 and 54.9 +/- 2.1 (P < 0.01). (2) The mRNA and protein expression levels of HPH1 and FIH-1 in severe pre-eclampsia group were all negatively correlated with mean arterial pressure (MAP) [the Spearman correlation coefficient was -0.854 (P < 0.01)], urinary protein per 24 hours [the Spearman correlation coefficient was -0.936 (P < 0.01)] and the occurr...Continue Reading

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