PMID: 16512994Mar 4, 2006Paper

Clinical significance of immunohistochemical expression of hypoxia-inducible factor-1alpha as a prognostic marker in rectal adenocarcinoma

Clinical Colorectal Cancer
Xue-guan LuChong Deng

Abstract

Hypoxia-inducible factor-1alpha (HIF-1alpha), a subunit of hypoxia-inducible factor-1 (HIF-1), furnishes tumor cells with the means of adapting to stress parameters, such as tumor hypoxia, and promotes critical steps in tumor progression and aggressiveness by inducing angiogenesis and regulating energy metabolism. In this study, we investigated the relationship between HIF-1alpha and vascular endothelial growth factor (VEGF) and clinicopathologic characteristics, and evaluated the role of HIF-1alpha expression in patients with rectal adenocarcinoma. The immunohistochemical expression of HIF-1alpha and VEGF was evaluated in 30 formalin-fixed, paraffin-embedded postoperative rectal adenocarcinoma tissue samples. Correlations with clinicopathologic characteristics were determined by cross-tabulations. The impact of the immunoreactivity of HIF-1alpha with regard to the overall survival and local control endpoints was determined by univariate analyses. Increased HIF-1alpha expression was strongly associated with VEGF positivity (P = 0.002), Dukes stage (P = 0.017), and lymph node metastasis (P = 0.001). No correlation was found between the level of HIF-1alpha expression and histologic grade (P = 0.63). The Kaplan-Meier curves showed...Continue Reading

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Citations

Dec 20, 2012·Experimental and Therapeutic Medicine·Fei-Wu KangZuo-Lin Wang
Dec 17, 2009·Scandinavian Journal of Gastroenterology·E KorkeilaS Pyrhönen
Aug 10, 2012·Diseases of the Colon and Rectum·Steven A Lee-KongJosé G Guillem
Apr 9, 2014·Virchows Archiv : an International Journal of Pathology·Anna NovellXavier Matias-Guiu
Feb 6, 2016·International Journal of Molecular Medicine·Xin LiuQiuran Xu
Oct 18, 2016·Journal of Radiation Oncology·Ikuko KatoRichard K Severson

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