PMID: 4596743Dec 1, 1972

Clinical significance of in vitro synergism between antibiotics in gram-negative infections

Antimicrobial Agents and Chemotherapy
J KlasterskyD Daneau

Abstract

Five combinations of antibiotics (ampicillin/gentamicin, cephalothin/gentamicin, carbenicillin/gentamicin, polymyxin/carbenicillin, and carbenicillin/cephalothin) were investigated in vitro and in 148 severe infectious episodes caused by gram-negative bacilli in patients with disseminated cancer. The use of combinations that were synergistic in vitro against the offending microorganism (synergy was defined as occurring when the minimal inhibitory concentration of each of the drugs in the combination was one-quarter or less of the minimal inhibitory concentration of each drug alone) was associated with a significantly better response to antibacterial therapy (P < 0.01) than the use of combinations that were not synergistic against the causative agent.

References

May 1, 1968·Archives of Internal Medicine·M A Freid, K L Vosti
Jan 1, 1968·Annual Review of Pharmacology·E Jawetz
Dec 1, 1970·The American Journal of the Medical Sciences·J KlasterskyD Daneau
Aug 1, 1971·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J KlasterskyM Stilmant
Dec 1, 1963·The American Journal of the Medical Sciences·R J BULGER, W M Kirby

Citations

Apr 1, 1976·Journal of Clinical Pharmacology·J KlasterskyE Yourassowsky
Nov 1, 1994·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·J Klastersky
May 1, 1994·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·J Klastersky
Jan 1, 1979·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J Klastersky
Jan 1, 1982·Infection·J A Hoogkamp-Korstanje, N A Westerdaal
Feb 1, 1986·European Journal of Clinical Microbiology·P Dejace, J Klastersky
Feb 1, 1986·European Journal of Clinical Microbiology·K MachkaI Braveny
Aug 1, 1982·European Journal of Clinical Microbiology·K MachkaI Braveny
Nov 1, 1989·Radiologic Clinics of North America·T C McLoud
Jan 1, 1987·Indian Pediatrics·U K NamdeoS Namdeo
Dec 16, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A JimenoH Cortés-Funes
Jul 22, 1978·Lancet·R VanhoffE Yourassowsky
Mar 23, 2013·Journal of Medicinal Chemistry·Zubida M Al-MajdoubJill Barber
Apr 11, 1985·The New England Journal of Medicine·J S Wolfson, M N Swartz
Sep 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Matthew HegrenessRoy Kishony
Dec 1, 1978·The Journal of Applied Bacteriology·L B QuesnelP Buddhavudhikrai
Sep 2, 2010·Antimicrobial Agents and Chemotherapy·James B AggenHeinz E Moser
Dec 1, 1976·Antimicrobial Agents and Chemotherapy·R M D'AlessandriR M Kluge
Oct 1, 1977·Antimicrobial Agents and Chemotherapy·J KlasterskyJ M Prevost
May 1, 1978·Antimicrobial Agents and Chemotherapy·H S Heineman, W M Lofton
Aug 1, 1980·Antimicrobial Agents and Chemotherapy·J C WadeP H Wiernik
Oct 1, 1984·Antimicrobial Agents and Chemotherapy·T M HootonG W Counts
Mar 1, 1987·Antimicrobial Agents and Chemotherapy·F M GordinM A Sande
May 1, 1989·Antimicrobial Agents and Chemotherapy·S C HarrisM G Rinaldi
Jun 1, 1990·Antimicrobial Agents and Chemotherapy·G R AronoffM E Brier
Jun 1, 1992·Antimicrobial Agents and Chemotherapy·H AnwarJ W Costerton
Nov 1, 1973·Antimicrobial Agents and Chemotherapy·R D LibkeW M Kirby
Feb 1, 1974·Antimicrobial Agents and Chemotherapy·J KlasterskyD Daneau
Jun 1, 1976·Antimicrobial Agents and Chemotherapy·J A RetsemaJ E Lynch
Jul 6, 2012·Clinical Microbiology Reviews·Pranita D TammaLisa L Maragakis
Mar 1, 1983·The Journal of Clinical Investigation·W M Scheld, M A Sande
May 27, 2014·Therapeutic Delivery·Misagh Alipour, Zacharias E Suntres
Jan 1, 1974·Scandinavian Journal of Infectious Diseases·J KlasterskyE Mouawad
Jan 1, 1988·Cancer Investigation·M RubinP A Pizzo
Feb 5, 2011·International Journal of Antimicrobial Agents·Ronit MarcusLeonard Leibovici
May 1, 1980·The American Journal of Medicine·L J LoveP H Wiernik
Jul 15, 1985·The American Journal of Medicine·A L Baltch, R P Smith
Jul 28, 1986·The American Journal of Medicine·G P Bodey
Jul 25, 1988·The American Journal of Medicine·J Klastersky
Aug 1, 1986·The American Journal of Medicine·P G JonesG P Bodey
Dec 1, 1978·The American Journal of Medicine·R G Strauss
Jun 1, 1973·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J KlasterskyC Hensgens
Sep 1, 1973·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J KlasterskyD Daneau
Aug 1, 1984·European Journal of Cancer & Clinical Oncology·H C StandifordS C Schimpff
Oct 1, 1996·Journal of Chemotherapy·A Cometta, M P Glauser
Aug 1, 1985·Burns, Including Thermal Injury·J F HansbroughJ A Boswick
Nov 1, 1982·Bulletin of the New York Academy of Medicine·S C Schimpff
May 1, 1994·Pediatric Hematology and Oncology·N S RajeS H Advani
Dec 31, 1987·The New England Journal of Medicine·EORTC International Antimicrobial Therapy Cooperative GroupS H Zinner
Apr 1, 1988·Critical Care Clinics·M C Robson
Sep 1, 1983·Clinical Pediatrics·S B Fitzpatrick, B J Rosenstein
Mar 16, 2001·Expert Opinion on Pharmacotherapy·V JønssonA Wiik
Nov 1, 1989·Indian Journal of Pediatrics·V P Choudhry, S Choudhary
Nov 1, 1988·Indian Journal of Pediatrics·K ChughS C Arya
May 1, 1990·The Journal of International Medical Research·L A Mandell
May 10, 2017·BMC Microbiology·Casey BepplerPamela J Yeh

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Antibiotics
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Drug Augmentation
Malignant Neoplasms

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