Clinical Significance of Interleukin-6 in the Diagnosis of Sepsis and Discriminating Sepsis Induced by Gram-negative Bacteria

The Pediatric Infectious Disease Journal
Wen-Xia ShaoXian-Jun Wang

Abstract

To discuss the clinical significance of interleukin (IL)-6 in the differential diagnosis of sepsis and its capability of differentiating the sepsis induced by Gram-negative bacteria from that induced by Gram-positive bacteria. A total of 379 children with sepsis were involved in this study to form the case group, and their C-reactive protein (CRP), procalcitonin (PCT) and IL-6 levels before antibiotics and after recovery were checked. Receiver operating characteristic curve was applied to evaluate the significance of CRP, PCT and IL-6 in the differential diagnosis of sepsis and their capability of differentiating the sepsis induced by Gram-negative bacteria from that induced by Gram-positive bacteria. When these 3 indicators were applied to the differential diagnosis of sepsis, the area under the curve (AUC) of IL-6, PCT and CRP was 0.881, 0.877 and 0.754, respectively. The combination of IL-6 and PCT presented highest diagnostic efficiency. CRP, PCT and IL-6 levels in children with sepsis induced by Gram-negative bacteria were significantly higher than those in children with sepsis induced by Gram-positive bacteria. CRP, IL-6 and PCT are applicable to the differential diagnosis of sepsis and differentiating the sepsis induced ...Continue Reading

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Citations

Feb 13, 2020·Biochemical Society Transactions·Inge GrondmanMihai G Netea
Jun 18, 2020·Frontiers in Veterinary Science·Roberta TroiaRobert Goggs
Feb 6, 2021·The Journal of Infection·ChunXiang WuJu Cao
Aug 5, 2021·BMC Infectious Diseases·Elena María Rincón-LópezUNKNOWN F-DREP Study Group

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